{"id":"W2947852075","doi":"10.1615/critrevimmunol.2019030480","title":"TAOK3, a Regulator of LCK–SHP-1 Crosstalk during TCR Signaling","year":2019,"lang":"en","type":"review","venue":"Critical Reviews in Immunology","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research; Conselho Nacional de Desenvolvimento Científico e Tecnológico","keywords":"Crosstalk; T-cell receptor; Cell biology; Regulator; Protein tyrosine phosphatase; Signal transduction; Effector; Immunoreceptor tyrosine-based activation motif; Negative regulator; Proto-oncogene tyrosine-protein kinase Src; Downregulation and upregulation; T cell; Tyrosine kinase; Syk; Biology; Immunology; Biochemistry; Immune system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"category_scores_codex":[0.001315607,0.001329478,0.008778594,0.0009083299,0.0002302042,0.00003259455,0.001766159,0.003283132,0.00264586],"category_scores_gemma":[0.002782338,0.001098239,0.00182779,0.0008633702,0.002607972,0.0001745948,0.0009791924,0.003152111,0.006039199],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003207503,"about_ca_system_score_gemma":0.0005254303,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005514516,"about_ca_topic_score_gemma":0.000008024203,"domain_scores_codex":[0.9894055,0.002939873,0.004198779,0.001534437,0.00009673954,0.001824742],"domain_scores_gemma":[0.9942356,0.002321446,0.001108811,0.002076881,0.0001961419,0.00006113402],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002029233,0.0009395092,0.00001812999,0.06467398,0.001161818,0.0001416611,0.0002128579,4.428899e-7,0.3186727,0.01249032,0.0007391532,0.6007466],"study_design_scores_gemma":[0.001221339,0.0003354609,0.000007479212,0.02520172,0.000968258,0.000896553,0.00005191733,1.441793e-7,0.004040126,0.0003022757,0.9660309,0.0009438269],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001088789,0.9920425,0.00003000158,0.0000571543,0.00376084,0.00197973,0.0001053825,0.00009640683,0.0008391404],"genre_scores_gemma":[0.001533022,0.9932722,0.0002129326,0.00006031263,0.0000968968,0.0004128268,0.0002896524,0.0001554754,0.003966668],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9652917,"threshold_uncertainty_score":0.9999456,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.053207239675427,"score_gpt":0.3405985060562937,"score_spread":0.2873912663808667,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}