{"id":"W2947852075","doi":"10.1615/critrevimmunol.2019030480","title":"TAOK3, a Regulator of LCK–SHP-1 Crosstalk during TCR Signaling","year":2019,"lang":"en","type":"review","venue":"Critical Reviews in Immunology","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research; Conselho Nacional de Desenvolvimento Científico e Tecnológico","keywords":"Crosstalk; T-cell receptor; Cell biology; Regulator; Protein tyrosine phosphatase; Signal transduction; Effector; Immunoreceptor tyrosine-based activation motif; Negative regulator; Proto-oncogene tyrosine-protein kinase Src; Downregulation and upregulation; T cell; Tyrosine kinase; Syk; Biology; Immunology; Biochemistry; Immune system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002761845,0.0006620718,0.0007257831,0.0008988369,0.0001876682,0.0007830312,0.0005977761,0.0007881645,0.001422717],"category_scores_gemma":[0.0001959533,0.0001946596,0.0002405179,0.0008832575,0.0003501275,0.000813448,0.0004143697,0.001249662,0.001769201],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006450907,"about_ca_system_score_gemma":0.0006553134,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005108343,"about_ca_topic_score_gemma":0.0006088345,"domain_scores_codex":[0.9999107,0.00001068219,0.00001079014,0.00001789475,0.00003371026,0.00001613126],"domain_scores_gemma":[0.9999299,0.00002042635,0.0000137999,0.000002308206,0.00002048195,0.00001306608],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001491756,0.00005022516,0.0002602827,0.01430384,0.00006196671,0.0004647303,0.00007693032,0.0006334604,0.0235972,0.008230896,0.02830964,0.9238616],"study_design_scores_gemma":[0.00001396571,0.00008698455,0.001092585,0.0009271387,0.00004857597,0.001243505,0.00003764189,0.0001190289,0.003359765,0.002147777,0.9909074,0.00001562195],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0004425944,0.9966942,0.0002426154,0.0002409552,0.0004141201,0.000005130685,0.00002104971,0.00001386712,0.001925498],"genre_scores_gemma":[0.002346742,0.9954414,0.0002150016,0.0001886954,0.0003047009,0.000008427096,0.00005537126,0.000002856542,0.001436813],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001422717,"threshold_uncertainty_score":0.004759431,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.053207239675427,"score_gpt":0.3405985060562937,"score_spread":0.2873912663808667,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}