{"id":"W2947874495","doi":"10.1056/nejmoa1817249","title":"Daratumumab plus Lenalidomide and Dexamethasone for Untreated Myeloma","year":2019,"lang":"en","type":"article","venue":"New England Journal of Medicine","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":987,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; University of Calgary","funders":"Janssen Research and Development; National Cancer Institute; Incyte; Celgene; Gilead Sciences; Pharmacyclics; Sanofi; Bristol-Myers Squibb; Chugai Pharmaceutical; Amgen","keywords":"Daratumumab; Lenalidomide; Dexamethasone; Multiple myeloma; Medicine; Oncology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007512631,0.0001788341,0.0007339016,0.0002674288,0.00005011362,0.00001230232,0.00008378131,0.00007492172,0.0003466068],"category_scores_gemma":[0.0008560343,0.0001041936,0.0000861668,0.0001523081,0.00009418672,0.00009499954,0.00002067757,0.0002746453,0.00001240482],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009926206,"about_ca_system_score_gemma":0.0002742813,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001175642,"about_ca_topic_score_gemma":0.00002410542,"domain_scores_codex":[0.9985092,0.0000696116,0.000452146,0.0001730082,0.0004958677,0.0003001434],"domain_scores_gemma":[0.9980557,0.0006265852,0.0002204288,0.0001850399,0.0003031996,0.0006090216],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.05121771,0.0002381676,0.1201409,0.0005190739,0.001737972,0.001603203,0.001721988,0.00002376748,0.03700902,0.0004014504,0.01774562,0.7676411],"study_design_scores_gemma":[0.7467136,0.01769709,0.1058806,0.001818335,0.0009580074,0.008747611,0.0004980383,0.001349428,0.006059785,0.0009654457,0.1090375,0.0002744842],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.984702,0.003959769,0.0007852026,0.007697423,0.0003344311,0.0006218995,0.000006452586,0.00001324009,0.001879567],"genre_scores_gemma":[0.9910707,0.0005707598,0.002891176,0.0003120337,0.001753728,0.000003342313,0.00002051452,0.00002459422,0.003353082],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7673666,"threshold_uncertainty_score":0.4248892,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03083090465145425,"score_gpt":0.32272611846995,"score_spread":0.2918952138184958,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}