{"id":"W2947918745","doi":"10.1200/jco.2019.37.15_suppl.tps597","title":"NATALEE: Phase III study of ribociclib (RIBO) + endocrine therapy (ET) as adjuvant treatment in hormone receptor–positive (HR+), human epidermal growth factor receptor 2–negative (HER2–) early breast cancer (EBC).","year":2019,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency; University of Calgary","funders":"","keywords":"Medicine; Letrozole; Anastrozole; Internal medicine; Randomization; Goserelin; Breast cancer; Cancer; Oncology; Metastatic breast cancer; Adjuvant; Randomized controlled trial; Tamoxifen","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001399448,0.001248705,0.001218877,0.0003459471,0.0002450104,0.0008528779,0.00111269,0.001146569,0.007687735],"category_scores_gemma":[0.0007503151,0.0003685037,0.001308124,0.0002386893,0.0005986998,0.0008164579,0.0004267348,0.002116974,0.001418052],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006972948,"about_ca_system_score_gemma":0.001056139,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007454832,"about_ca_topic_score_gemma":0.0042431,"domain_scores_codex":[0.9996849,0.000173949,0.00001077294,0.00003532344,0.00003619962,0.00005880745],"domain_scores_gemma":[0.9995977,0.00006545975,0.0001030089,0.00004059832,0.00002429214,0.0001689721],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.7584733,0.05688901,0.005693479,0.001980708,0.001999318,0.0002724176,0.0002044032,0.002753502,0.0377936,0.001466453,0.01436462,0.1181093],"study_design_scores_gemma":[0.7824799,0.1888828,0.01037763,0.0001085831,0.0005992347,0.0004123143,0.00006553951,0.0009723409,0.002958361,0.0004802517,0.01262332,0.00003969872],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9611257,0.01005277,0.001358754,0.002167636,0.0005221975,0.006548102,0.005610729,0.0003731827,0.01224082],"genre_scores_gemma":[0.9437929,0.007394568,0.004319111,0.004897923,0.0004225673,0.01086862,0.01076181,0.000102292,0.01744027],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007687735,"threshold_uncertainty_score":0.02571809,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07142779416144623,"score_gpt":0.473287293458567,"score_spread":0.4018594992971208,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}