{"id":"W2947924669","doi":"10.1186/s40425-019-0595-z","title":"Level of neo-epitope predecessor and mutation type determine T cell activation of MHC binding peptides","year":2019,"lang":"en","type":"article","venue":"Journal for ImmunoTherapy of Cancer","topic":"vaccines and immunoinformatics approaches","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Metropolitan University","funders":"","keywords":"Epitope; Antigen; Computational biology; Major histocompatibility complex; T cell; CD8; Cancer immunotherapy; Immunotherapy; MHC class I; Peptide; Biology; Epitope mapping; Immunology; Immune system; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006252502,0.0006023418,0.0005743215,0.000775523,0.0002650993,0.001094603,0.0005295963,0.0006543485,0.001933515],"category_scores_gemma":[0.002060327,0.0001343507,0.0004527982,0.0006524978,0.0001427207,0.0005162007,0.0002746853,0.0005710517,0.0009876221],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005864595,"about_ca_system_score_gemma":0.0004050404,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002032117,"about_ca_topic_score_gemma":0.002038016,"domain_scores_codex":[0.9996512,0.00004602139,0.00002316812,0.0001414735,0.00008680216,0.00005140298],"domain_scores_gemma":[0.9992326,0.0004772115,0.00008855875,0.00005823948,0.0001103841,0.00003299263],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002090516,0.000733957,0.4084917,0.001598726,0.0006113402,0.0004012155,0.0001605502,0.1537033,0.1002839,0.001048174,0.01994095,0.3109356],"study_design_scores_gemma":[0.00008726757,0.0004144626,0.1352731,0.0001207327,0.0003459887,0.0008194602,0.000157836,0.7698172,0.07868703,0.00227409,0.01195812,0.00004468257],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9561659,0.002247352,0.02257396,0.0002560184,0.00005163546,0.00009573656,0.01368582,0.001272688,0.003650889],"genre_scores_gemma":[0.9482319,0.0006282668,0.02335788,0.000140655,0.00002133911,0.0001634064,0.02651576,0.00008954624,0.0008512338],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002032117,"threshold_uncertainty_score":0.006468236,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03674745316633686,"score_gpt":0.3049631146487553,"score_spread":0.2682156614824184,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}