{"id":"W2947929925","doi":"10.1126/sciimmunol.aaw0902","title":"CTLA-4–mediated transendocytosis of costimulatory molecules primarily targets migratory dendritic cells","year":2019,"lang":"en","type":"article","venue":"Science Immunology","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":152,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Rosetrees Trust; Horizon 2020; Medical Research Council; Diabetes UK; Wellcome Trust","keywords":"Cell biology; Dendritic cell; Follicular dendritic cells; Antigen; Biology; Immunology; Antigen-presenting cell; Immune system; T cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","sts","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0006223381,0.000415556,0.0008098095,0.0006905832,0.0003299459,0.00002066041,0.001436408,0.0005558783,0.001912535],"category_scores_gemma":[0.0001487801,0.000385773,0.000222126,0.0008606029,0.004796566,0.0003069634,0.0002939398,0.0006890232,0.00624478],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001421966,"about_ca_system_score_gemma":0.0007077833,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000237071,"about_ca_topic_score_gemma":0.00001724035,"domain_scores_codex":[0.9965308,0.0003530291,0.0007683727,0.0009111745,0.0001465359,0.001290146],"domain_scores_gemma":[0.9978653,0.0004519398,0.0003330523,0.0009676213,0.0003252858,0.00005678669],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002103889,0.0002971903,0.002182279,0.00003259606,0.0001720816,0.00001191425,0.0004620471,0.00002222597,0.9943536,0.0008821954,0.0003700668,0.001003409],"study_design_scores_gemma":[0.002347411,0.0007044368,0.003252798,0.0000370781,0.00005164971,0.0001117503,0.0004176584,0.00002208877,0.980564,0.000150252,0.01193712,0.0004037335],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9808932,0.01191747,0.00008724676,0.0001629308,0.003721347,0.0005243561,0.00005275577,0.0001491407,0.002491565],"genre_scores_gemma":[0.9976195,0.0003422107,0.0002243936,0.000294932,0.00001322417,0.00002643686,0.00007308389,0.00003389516,0.001372304],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01672634,"threshold_uncertainty_score":0.9998594,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006701379914209127,"score_gpt":0.2134695256506123,"score_spread":0.2067681457364031,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}