{"id":"W2947931616","doi":"10.1101/655670","title":"Influence of genetic variants on gene expression in human pancreatic islets – implications for type 2 diabetes","year":2019,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Medical Research Council; Alberta Diabetes Foundation; Vetenskapsrådet; European Commission; University of Oxford; Novo Nordisk; National Institute for Health and Care Research; National Human Genome Research Institute; Wellcome Trust; Stiftelsen för Strategisk Forskning; AstraZeneca; European Foundation for the Study of Diabetes; University of Michigan; National Institutes of Health; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Åke Wiberg Stiftelse; Canadian Institutes of Health Research; American Diabetes Association","keywords":"Expression quantitative trait loci; Biology; Genome-wide association study; Genetics; Islet; TCF7L2; Genetic association; Gene; Computational biology; Enhancer; Single-nucleotide polymorphism; Gene expression; Genotype; Insulin; Endocrinology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005393295,0.0001174864,0.0002017969,0.0002317006,0.00009919878,0.0005403298,0.00007759906,0.0001363288,0.002952331],"category_scores_gemma":[0.0009557114,0.00007838271,0.0002036866,0.0005118708,0.0001714141,0.00009987839,0.000216522,0.0002191763,0.0003154197],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001017392,"about_ca_system_score_gemma":0.00007684207,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007764687,"about_ca_topic_score_gemma":0.0007246086,"domain_scores_codex":[0.9997115,0.00008719761,0.00001196707,0.0001215929,0.00004721167,0.00002066218],"domain_scores_gemma":[0.9995577,0.0002810888,0.0000498076,0.00006983502,0.00001777444,0.00002378644],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001969205,0.00007815073,0.4620543,0.000284745,0.0006723509,0.001289397,0.0004428807,0.00403924,0.4544969,0.002418,0.003457041,0.0687978],"study_design_scores_gemma":[0.00004455094,0.00008967325,0.9556108,0.00003107222,0.0002031008,0.0009531941,0.0002665201,0.004876913,0.02827088,0.004122862,0.005510436,0.00001999397],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9843003,0.001456991,0.007527236,0.0003488555,0.00005577091,0.000006098125,0.003812935,0.0001086933,0.002383172],"genre_scores_gemma":[0.9951975,0.0003861515,0.002129998,0.0001478586,0.00003208713,0.00000494826,0.001344869,0.00005911021,0.0006976262],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002952331,"threshold_uncertainty_score":0.009876549,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02229161184468513,"score_gpt":0.2644594698719972,"score_spread":0.2421678580273121,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}