{"id":"W2947953181","doi":"10.1186/s13063-019-3394-4","title":"Study protocol for a randomized, blinded, controlled trial of ketamine for acute painful crisis of sickle cell disease","year":2019,"lang":"en","type":"article","venue":"Trials","topic":"Hemoglobinopathies and Related Disorders","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"Medicine; Ketamine; Randomized controlled trial; Vaso-occlusive crisis; Anesthesia; Analgesic; Opioid; Morphine; Sickle cell anemia; Acute pain; Clinical trial; Acute chest syndrome; Disease; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.007684092,0.0002454832,0.004281638,0.0001690279,0.00003485869,0.000009901965,0.0001223907,0.0001528072,0.0002152762],"category_scores_gemma":[0.00459339,0.0001449306,0.001665674,0.0001443444,0.00006316371,0.00004033977,0.00002566439,0.00008698185,0.000006379506],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001765053,"about_ca_system_score_gemma":0.0003378751,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001839613,"about_ca_topic_score_gemma":9.220335e-7,"domain_scores_codex":[0.9961329,0.0006990275,0.002226839,0.0003113189,0.0003640765,0.0002658901],"domain_scores_gemma":[0.9939159,0.003815643,0.001259376,0.0004643695,0.0003874001,0.0001573655],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9883718,0.004485924,0.00005131993,0.0008434646,0.001894825,0.00000295572,0.0003279452,0.00001775212,0.001068495,0.00005630448,0.002470068,0.0004091473],"study_design_scores_gemma":[0.9808787,0.007676963,0.000005661393,0.0000939549,0.005801227,3.791421e-7,0.0007911519,0.0003290332,0.00253128,0.0003248702,0.001425624,0.0001411438],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.1522998,0.00004931574,0.0005966806,0.0005225294,0.0002880421,0.8457137,0.0001061983,0.00002696082,0.0003967408],"genre_scores_gemma":[0.290025,0.00001128454,0.0003755629,0.0000995108,0.0002287117,0.7067781,0.00002012799,0.00004087799,0.002420776],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.1389356,"threshold_uncertainty_score":0.59101,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05409000657302793,"score_gpt":0.4041102364368713,"score_spread":0.3500202298638433,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}