{"id":"W2947964391","doi":"10.1016/j.copbio.2018.12.002","title":"Protein engineers turned evolutionists—the quest for the optimal starting point","year":2019,"lang":"en","type":"review","venue":"Current Opinion in Biotechnology","topic":"Genomics and Phylogenetic Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":133,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Defense Threat Reduction Agency; Azrieli Foundation; Weizmann Institute of Science","keywords":"Directed evolution; Protein engineering; Evolutionism; Directed Molecular Evolution; Computational biology; Computer science; Molecular evolution; Synthetic biology; Broad spectrum; Biology; Phylogenetic tree; Enzyme; Evolutionary biology; Chemistry; Biochemistry; Combinatorial chemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004123106,0.0003607963,0.0005694059,0.0001039785,0.0001656827,0.00002795951,0.0006971199,0.0005968398,0.000002594426],"category_scores_gemma":[0.0002136668,0.0002224655,0.0003283642,0.0001896196,0.00024026,6.895503e-7,0.0003959089,0.0004693281,0.00001172973],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000623758,"about_ca_system_score_gemma":0.0001952016,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008987338,"about_ca_topic_score_gemma":0.000005450127,"domain_scores_codex":[0.9983486,0.00007984292,0.0005233657,0.0005523103,0.0000815258,0.0004143586],"domain_scores_gemma":[0.998808,0.00008370309,0.0003018348,0.0007269046,0.00005547443,0.00002412527],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00003646052,0.0001014336,0.000009080702,0.008501442,0.0004068887,1.910761e-7,0.00007237915,0.0001991901,0.001002082,0.004894791,0.0083666,0.9764094],"study_design_scores_gemma":[0.0002246923,0.0001612335,0.000004921545,0.00107105,0.00007121095,0.000007651977,0.00006200479,0.0001109104,0.0001816545,0.00007493082,0.9977621,0.0002676016],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000108423,0.9913813,0.002086268,0.0008556769,0.002921651,0.002517787,0.0001093622,0.00001215585,0.000007306297],"genre_scores_gemma":[0.000397768,0.9972124,0.0004100792,0.00001101325,0.0005620462,0.001147402,0.0001719993,0.00004336183,0.00004398421],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9893956,"threshold_uncertainty_score":0.907188,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0636561580099841,"score_gpt":0.3458091587535944,"score_spread":0.2821530007436103,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}