{"id":"W2947975377","doi":"10.1200/jco.2019.37.15_suppl.2021","title":"Full enrollment results from an extended phase I, multicenter, open label study of marizomib (MRZ) with temozolomide (TMZ) and radiotherapy (RT) in newly diagnosed glioblastoma (GBM).","year":2019,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Medicine; Temozolomide; Internal medicine; Adverse effect; Ataxia; Common Terminology Criteria for Adverse Events; Phases of clinical research; Clinical endpoint; Glioma; Toxicity; Surgery; Clinical trial; Radiation therapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00340987,0.002294748,0.002420983,0.000313591,0.001002648,0.001033701,0.001011209,0.001331588,0.01814545],"category_scores_gemma":[0.001432789,0.0007927382,0.001002723,0.0004674983,0.0008751274,0.001297495,0.0007191481,0.002752649,0.004121222],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009186951,"about_ca_system_score_gemma":0.003543307,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001311966,"about_ca_topic_score_gemma":0.003057974,"domain_scores_codex":[0.9991058,0.0003954921,0.00005357066,0.0001461424,0.000115409,0.0001836156],"domain_scores_gemma":[0.9989826,0.0001016028,0.0001168475,0.0001105755,0.00008357978,0.0006047114],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7879909,0.05815339,0.008243265,0.0007284485,0.001095365,0.0003469703,0.0003014152,0.001264394,0.04945217,0.0002100655,0.02528711,0.0669264],"study_design_scores_gemma":[0.6201321,0.3063779,0.03759453,0.00006265373,0.0008624913,0.0003684429,0.00008129139,0.0008845131,0.005908522,0.0003334434,0.02733377,0.00006034453],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9007533,0.002548797,0.002832147,0.001189152,0.0003969688,0.04013911,0.04351553,0.0004570525,0.008168093],"genre_scores_gemma":[0.8423841,0.001753618,0.007809918,0.0041245,0.0004706733,0.04950366,0.07331286,0.0002376061,0.02040304],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01814545,"threshold_uncertainty_score":0.06070256,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08167081924197511,"score_gpt":0.4673442281530484,"score_spread":0.3856734089110733,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}