{"id":"W2947993787","doi":"10.1186/s13395-019-0198-x","title":"Preclinical rationale for entinostat in embryonal rhabdomyosarcoma","year":2019,"lang":"en","type":"article","venue":"Skeletal Muscle","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"National Institutes of Health; National Cancer Institute; St. Baldrick's Foundation","keywords":"Rhabdomyosarcoma; Medicine; Cancer research; Alveolar rhabdomyosarcoma; Histone deacetylase; Pathology; Sarcoma; Biology; Histone","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002917185,0.0001004715,0.0001202322,0.00005319181,0.00003569911,0.00001568391,0.0001574185,0.0001233337,0.0001494508],"category_scores_gemma":[0.0002158918,0.0001044175,0.0001262798,0.00007573567,0.00006233774,0.000005655183,0.00009094791,0.0001124963,0.0001706786],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000232988,"about_ca_system_score_gemma":0.0001247451,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009412556,"about_ca_topic_score_gemma":0.00006385784,"domain_scores_codex":[0.9989007,0.00005706438,0.0002263597,0.0003583637,0.0001724458,0.0002850339],"domain_scores_gemma":[0.9994979,0.00006673033,0.00003803092,0.0002586569,0.00007078322,0.00006790001],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001392309,0.0002428256,0.003634064,0.00006261116,0.00001932185,0.000003345155,0.00004685767,0.00007653782,0.9805961,0.0003563136,0.006395147,0.008427653],"study_design_scores_gemma":[0.004964821,0.001180074,0.06514511,0.00004309435,0.000007737188,0.00001284166,0.0001168637,0.001124569,0.2229923,0.0003981017,0.7034734,0.0005409638],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960222,0.0002058892,0.0002681495,0.0002651385,0.0002287389,0.0006205429,0.00003996511,0.000008139621,0.002341248],"genre_scores_gemma":[0.9925989,0.00001121608,0.0009397746,0.0001434481,0.0002544189,0.00009484325,0.0002839014,0.00002208958,0.005651419],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7576038,"threshold_uncertainty_score":0.4258022,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01673549571973987,"score_gpt":0.3108282929575436,"score_spread":0.2940927972378037,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}