{"id":"W2947994919","doi":"10.3390/pr7060331","title":"Development of Hydrophilic Drug Encapsulation and Controlled Release Using a Modified Nanoprecipitation Method","year":2019,"lang":"en","type":"article","venue":"Processes","topic":"Advanced Drug Delivery Systems","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"Jiangsu University of Science and Technology; Jiangsu University","keywords":"Polyethylene glycol; PLGA; Lactic acid; Polymer; Drug; Dextran; Drug delivery; PEG ratio; Nanoparticle; Materials science; Chemical engineering; Chemistry; Chromatography; Nanotechnology; Organic chemistry; Pharmacology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006237961,0.0001431086,0.0003400539,0.0001122666,0.0001087425,0.000008580475,0.00008211592,0.0001076352,0.00008241297],"category_scores_gemma":[0.0002220058,0.0001318558,0.00002637643,0.000206345,0.00003712406,0.0002147713,0.00003472677,0.0001402818,0.00001796996],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000386946,"about_ca_system_score_gemma":0.000192326,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007970876,"about_ca_topic_score_gemma":0.000006500331,"domain_scores_codex":[0.998768,0.0002251187,0.0004482036,0.0002450531,0.0001414989,0.0001721353],"domain_scores_gemma":[0.9987513,0.0005119134,0.0003313572,0.00008958529,0.000245302,0.00007049528],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002303687,0.0002651158,0.004371602,0.003050996,0.0002987034,0.000003299455,0.01580771,0.08411724,0.8564337,0.0004105859,0.00002483561,0.03291254],"study_design_scores_gemma":[0.01320953,0.00007351409,0.0003308115,0.0001947078,0.0002828701,0.00002417434,0.001783594,0.4663176,0.5028791,0.001507584,0.01283361,0.0005629214],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9838712,0.002372997,0.01181801,0.00003545587,0.000257081,0.000816813,0.000007478163,0.00004199623,0.0007789616],"genre_scores_gemma":[0.9794546,0.00009277876,0.0199583,0.00007464088,0.00003581974,0.00005057105,0.00001239424,0.00001313064,0.0003077786],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3822004,"threshold_uncertainty_score":0.5376922,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09907247891737657,"score_gpt":0.434513885645832,"score_spread":0.3354414067284554,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}