{"id":"W2948014205","doi":"10.1038/s41467-019-10241-w","title":"Atypical function of a centrosomal module in WNT signalling drives contextual cancer cell motility","year":2019,"lang":"en","type":"article","venue":"Nature Communications","topic":"Cellular Mechanics and Interactions","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Toronto Metropolitan University; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"Canada First Research Excellence Fund; Krembil Foundation; Government of Canada; Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; Genome Canada; Ontario Genomics; Ontario Genomics Institute","keywords":"Centrosome; Cell biology; Motility; Wnt signaling pathway; Biology; Cell polarity; Cell; Signal transduction; Cell cycle; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008791962,0.000199137,0.0001256443,0.0001464332,0.0002045668,0.0003206539,0.0001426316,0.0001982141,0.0009360295],"category_scores_gemma":[0.0001323184,0.0001263162,0.0001345556,0.0001045757,0.0002051844,0.000206405,0.0003427766,0.0002303428,0.0002468315],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005812772,"about_ca_system_score_gemma":0.0002668679,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008289941,"about_ca_topic_score_gemma":0.00248754,"domain_scores_codex":[0.9998808,0.00001262711,0.00000818304,0.00002366112,0.00003799544,0.00003667808],"domain_scores_gemma":[0.9999108,0.000007414802,0.00002768899,0.00001376137,0.00000855585,0.00003168865],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003871113,0.000002173964,0.0005947865,0.00001177957,0.00000237798,0.00009132265,0.000005391061,0.00008306216,0.9984158,0.0002035096,0.00001510483,0.0005359182],"study_design_scores_gemma":[0.000008386203,0.00005490496,0.01965793,0.000003858792,0.000009162056,0.0006953991,0.00003396506,0.001553356,0.9757589,0.0001397929,0.002078687,0.000005644643],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965372,0.0005477839,0.001768713,0.00005136498,0.000007174129,0.000004944999,0.0001204425,0.00004617184,0.0009162187],"genre_scores_gemma":[0.9987722,0.0001189846,0.000422424,0.00001062396,0.000001517655,0.000003241998,0.00007742682,0.000006881163,0.0005866435],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009360295,"threshold_uncertainty_score":0.004217505,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01024833594847429,"score_gpt":0.2689377587687601,"score_spread":0.2586894228202858,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}