{"id":"W2948040333","doi":"10.1002/art.41004","title":"Rapid and Sustained Long‐Term Efficacy and Safety of Canakinumab in Patients With Cryopyrin‐Associated Periodic Syndrome Ages Five Years and Younger","year":2019,"lang":"en","type":"article","venue":"Arthritis & Rheumatology","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"NIHR Great Ormond Street Hospital Biomedical Research Centre; Eli Lilly Canada; Chugai Pharmaceutical; National Institute for Health and Care Research; Swedish Orphan Biovitrum; Bristol-Myers Squibb; Eli Lilly and Company; CSL Behring; Novartis Pharma; Pfizer; Hospital for Sick Children; Alexion Pharmaceuticals; Sanofi; GlaxoSmithKline","keywords":"Canakinumab; Medicine; Pediatrics; Term (time); Internal medicine; Anakinra; Disease; Physics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009693931,0.0002587378,0.000622945,0.00009171439,0.0001805387,0.0002004491,0.0001374968,0.0003098876,0.0008010791],"category_scores_gemma":[0.001267852,0.00008359316,0.0003062539,0.00008757696,0.0001406009,0.0002577431,0.0001329416,0.0004188124,0.0001793317],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001952395,"about_ca_system_score_gemma":0.0002292456,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002820771,"about_ca_topic_score_gemma":0.0004448067,"domain_scores_codex":[0.9997465,0.00008300416,0.00003020658,0.00003683885,0.00004684895,0.00005663503],"domain_scores_gemma":[0.9993539,0.0001928823,0.0002125695,0.0000260158,0.00004765238,0.0001669985],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.1078147,0.009062434,0.5512178,0.001259015,0.001236617,0.001961113,0.0007175148,0.001446502,0.06743485,0.0001155915,0.001516209,0.2562177],"study_design_scores_gemma":[0.01268718,0.2460522,0.7243584,0.0001550575,0.0005980406,0.00330113,0.0001828506,0.001273572,0.008745866,0.0000426328,0.002582837,0.00002030745],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998108,0.001463228,0.00007210021,0.00003667186,0.00001013071,0.0000330084,0.00003492039,0.000004000568,0.0002379896],"genre_scores_gemma":[0.999123,0.0003563389,0.0001275847,0.00008598893,0.00002977372,0.0000318538,0.0001063177,9.833843e-7,0.0001381779],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009693931,"threshold_uncertainty_score":0.005126715,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.001581108073991472,"score_gpt":0.1750342016676603,"score_spread":0.1734530935936689,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}