{"id":"W2948040333","doi":"10.1002/art.41004","title":"Rapid and Sustained Long‐Term Efficacy and Safety of Canakinumab in Patients With Cryopyrin‐Associated Periodic Syndrome Ages Five Years and Younger","year":2019,"lang":"en","type":"article","venue":"Arthritis & Rheumatology","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"NIHR Great Ormond Street Hospital Biomedical Research Centre; Eli Lilly Canada; Chugai Pharmaceutical; National Institute for Health and Care Research; Swedish Orphan Biovitrum; Bristol-Myers Squibb; Eli Lilly and Company; CSL Behring; Novartis Pharma; Pfizer; Hospital for Sick Children; Alexion Pharmaceuticals; Sanofi; GlaxoSmithKline","keywords":"Canakinumab; Medicine; Pediatrics; Term (time); Internal medicine; Anakinra; Disease; Physics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008145805,0.0001383871,0.0003225682,0.00007311855,0.00004076457,0.00001314507,0.00005887887,0.0001420018,0.00002479047],"category_scores_gemma":[0.00004748976,0.0001384443,0.00001886201,0.0000621186,0.0002426742,0.0000130584,0.00009583963,0.00007869524,0.000001369707],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008654311,"about_ca_system_score_gemma":0.00004352648,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002676351,"about_ca_topic_score_gemma":0.0007111807,"domain_scores_codex":[0.9991081,0.00006572475,0.00022824,0.0002850465,0.00006422411,0.0002486014],"domain_scores_gemma":[0.9996221,0.00002215715,0.00009956874,0.0001593865,0.00005492194,0.00004186762],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004498898,0.00006309924,0.9903631,0.00004448546,0.00007391043,0.0000186707,0.0005194098,0.000001034373,0.0005017674,0.00004440479,0.00001913697,0.007901154],"study_design_scores_gemma":[0.007774242,0.0009439326,0.9904205,0.0001126244,0.00000893536,0.00007430856,0.0002299964,0.000002000672,0.0001239114,0.000007298576,0.000132883,0.0001693667],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945929,0.004937485,7.844142e-7,0.00004152088,0.00003984956,0.000309923,0.00001961104,0.000005055161,0.00005289484],"genre_scores_gemma":[0.9962671,0.003468168,0.00001212404,0.00003479203,0.000001068159,0.000007360574,0.0001479431,0.00001577756,0.0000456566],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007731787,"threshold_uncertainty_score":0.5645595,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.001581108073991472,"score_gpt":0.1750342016676603,"score_spread":0.1734530935936689,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}