{"id":"W2948055130","doi":"10.1176/appi.ajp.2019.18080957","title":"GWAS of Suicide Attempt in Psychiatric Disorders and Association With Major Depression Polygenic Risk Scores","year":2019,"lang":"en","type":"review","venue":"American Journal of Psychiatry","topic":"Suicide and Self-Harm Studies","field":"Psychology","cited_by":285,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Cilag; National Institute of Mental Health; Faculty of Medicine and Health, University of Sydney; NIHR Maudsley Biomedical Research Centre; Medical Research Council; Montreal Neurological Institute and Hospital; SUNY Downstate Medical Center; School of Medicine, Emory University; National Institutes of Health; Neuraxpharm; H. Lundbeck A/S; Assistance publique-Hôpitaux de Paris; Mitsubishi Tanabe Pharma Corporation; Rheinische Friedrich-Wilhelms-Universität Bonn; Johns Hopkins University; Université Paris Diderot; Universitetet i Bergen; Universitair Medisch Centrum Utrecht; Statens Serum Institut; GGZ inGeest; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; State University of New York; Queensland University of Technology; Institut National de la Santé et de la Recherche Médicale; Fresenius Medical Care North America; Trinity College Dublin; Vrije Universiteit Amsterdam; University of Oxford; J. Willard and Alice S. Marriott Foundation; King's College London; National Institute for Health and Care Research; Universitätsmedizin Göttingen; Teva Pharmaceutical Industries; Umeå Universitet; NorthShore University HealthSystem; Sunovion; Norges Teknisk-Naturvitenskapelige Universitet; Northwestern University; Mayo Foundation for Medical Education and Research; McGill University; Aarhus Universitet; Universität Basel; University of Louisville; University of Cincinnati; University of Pittsburgh; BrainsWay; Broad Institute; Lundbeckfonden; Assurex Health; Kaiser Permanente; Allergan; Rush University; F. Hoffmann-La Roche; Genomic Health; Westfälische Wilhelms-Universität Münster; Queensland Brain Institute; University of Queensland; Emory University; Massachusetts General Hospital; Wayne State University; Ministry of Education, India; Robert Bosch Stiftung; Novo Nordisk; University of Pennsylvania","keywords":"Bipolar disorder; Major depressive disorder; Psychiatry; Suicide attempt; Genome-wide association study; Mood disorders; Depression (economics); Schizophrenia (object-oriented programming); Psychology; Poison control; Mood; Clinical psychology; Medicine; Suicide prevention; Single-nucleotide polymorphism; Genotype; Anxiety; Genetics; Medical emergency","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0008695773,0.0005263422,0.002774985,0.00103942,0.00008035734,0.00002184891,0.0004344596,0.0002475042,0.00007870034],"category_scores_gemma":[0.00007733023,0.0003688411,0.0006160772,0.001151284,0.0001753013,0.0001138898,0.00006247683,0.001195276,0.00002468039],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001250099,"about_ca_system_score_gemma":0.0004261064,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00129127,"about_ca_topic_score_gemma":0.001238813,"domain_scores_codex":[0.9960732,0.0008358249,0.001628493,0.0004642689,0.0005223618,0.0004758071],"domain_scores_gemma":[0.9921509,0.0006614975,0.006502755,0.0004443183,0.000113518,0.0001270146],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000224567,0.000183107,0.7219333,0.0008469938,0.001246899,0.000003513491,0.0002995981,0.000002131271,6.863439e-8,0.00002498294,0.00130805,0.2739268],"study_design_scores_gemma":[0.006560108,0.005687217,0.8866475,0.008113755,0.0127914,0.0004763032,0.006728482,0.000001507147,2.585539e-7,0.0007950622,0.07046213,0.001736302],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.06147258,0.935467,0.0000359648,0.0002181667,0.001809179,0.0004277233,0.00004374801,0.00001086871,0.0005147893],"genre_scores_gemma":[0.01409835,0.9839971,0.001219459,0.00008274893,0.0003777457,0.0000188368,0.000006631199,0.00008726134,0.000111856],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.2721905,"threshold_uncertainty_score":0.9998764,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01489497069714733,"score_gpt":0.325765378376468,"score_spread":0.3108704076793207,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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