{"id":"W2948089261","doi":"10.1038/s42003-019-0442-2","title":"TRAV1-2+ CD8+ T-cells including oligoconal expansions of MAIT cells are enriched in the airways in human tuberculosis","year":2019,"lang":"en","type":"article","venue":"Communications Biology","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":86,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"National Heart, Lung, and Blood Institute; National Institute of Allergy and Infectious Diseases; Medical Research Council; Center for AIDS Research, University of Washington; Victor Daitz Foundation; Government of the United Kingdom; Harvard University Center for AIDS Research; Wellcome Trust; Department of Science and Technology, Ministry of Science and Technology, India; Harvard University; New Partnership for Africa's Development; Alliance for Accelerating Excellence in Science in Africa; African Academy of Sciences; U.S. Department of Veterans Affairs; South African Medical Research Council; Wellcome; Inyuvesi Yakwazulu-Natali; National Institutes of Health; U.S. Department of Health and Human Services","keywords":"Immunology; Mycobacterium tuberculosis; T-cell receptor; Cytotoxic T cell; Immune system; CD8; Biology; Population; Tuberculosis; T cell; Phenotype; Microbiology; Medicine; Pathology; In vitro; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0005540242,0.00015496,0.0003307607,0.0003392546,0.0001911981,0.000007465102,0.001005925,0.000309071,0.0009677827],"category_scores_gemma":[0.0000458899,0.0001256897,0.0001082053,0.0003678266,0.0003018363,0.0000820356,0.0003038248,0.0006911263,0.0004056352],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007212386,"about_ca_system_score_gemma":0.00003525212,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004607789,"about_ca_topic_score_gemma":0.0004458236,"domain_scores_codex":[0.9978372,0.001071818,0.000577631,0.0002255912,0.00002343087,0.0002642651],"domain_scores_gemma":[0.997696,0.0006918964,0.0002373892,0.001293791,0.00007121213,0.000009734314],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003093308,0.0003856419,0.01101879,0.000009611445,0.00003241785,2.068923e-7,0.001409959,0.00001963282,0.9785779,0.006789657,0.001365207,0.0003601021],"study_design_scores_gemma":[0.005499812,0.0007852067,0.09587791,0.0002623763,0.00009154,0.00005491798,0.02320575,0.0002334227,0.5754474,0.001978348,0.2957575,0.0008057303],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.982594,0.00173336,0.00003520924,0.001334076,0.0008351749,0.0004916746,0.00001448823,0.00002755165,0.01293447],"genre_scores_gemma":[0.9974069,0.0006205867,0.00007065738,0.0003835932,0.000008081311,0.00008176039,0.0002780233,0.00001126103,0.001139143],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4031304,"threshold_uncertainty_score":0.9999455,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0380080598538064,"score_gpt":0.2978615868837877,"score_spread":0.2598535270299813,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}