{"id":"W2948097970","doi":"10.3389/fimmu.2019.01345","title":"Phenotypic Evidence of T Cell Exhaustion and Senescence During Symptomatic Plasmodium falciparum Malaria","year":2019,"lang":"en","type":"article","venue":"Frontiers in Immunology","topic":"Malaria Research and Control","field":"Medicine","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"International Development Research Centre; University of Ghana; World Bank Group","keywords":"Immunology; Immune system; Senescence; CD8; Asymptomatic; Malaria; T cell; Immunosenescence; Biology; Plasmodium falciparum; CD28; Flow cytometry; Parasitemia; Phenotype; Medicine; Internal medicine; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001616378,0.0001443138,0.0001610136,0.0003455002,0.000196376,0.0001881414,0.00008419355,0.0001649511,0.0008139233],"category_scores_gemma":[0.0005090582,0.00008923941,0.00008805645,0.0002121492,0.0002507659,0.000139106,0.0002334076,0.0002512486,0.0001084659],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009910858,"about_ca_system_score_gemma":0.0001015615,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003873282,"about_ca_topic_score_gemma":0.0004014682,"domain_scores_codex":[0.9998907,0.00001857568,0.00001159257,0.00002689142,0.00002517418,0.00002709964],"domain_scores_gemma":[0.9996367,0.00006126947,0.000160808,0.00002452239,0.00004521909,0.00007163742],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0009630071,0.00006518593,0.3438159,0.0002239738,0.00002897511,0.001290686,0.001537374,0.0001228097,0.6383399,0.0002141961,0.0002689657,0.01312907],"study_design_scores_gemma":[0.000009919673,0.0006064923,0.9641681,0.0000139481,0.0000194346,0.005955509,0.0005449565,0.0002165752,0.02741539,0.0001195724,0.0009225155,0.000007642206],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991326,0.0002576365,0.0002275634,0.00001134086,0.00000206966,0.000005331997,0.0001082001,0.000005700933,0.0002496803],"genre_scores_gemma":[0.9993643,0.0001354924,0.0002072503,0.00001176785,0.000004605035,0.000007656309,0.0001290294,0.000002529772,0.0001372453],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008139233,"threshold_uncertainty_score":0.002722859,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008814571474409097,"score_gpt":0.2398375231833997,"score_spread":0.2310229517089906,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}