{"id":"W2948179469","doi":"10.3389/fbioe.2019.00131","title":"At the Intersection of Biomaterials and Gene Therapy: Progress in Non-viral Delivery of Nucleic Acids","year":2019,"lang":"en","type":"review","venue":"Frontiers in Bioengineering and Biotechnology","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":62,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Alberta Innovates; Cure Brain Cancer Foundation; University of Alberta","keywords":"Nucleic acid; Genetic enhancement; Gene delivery; Intersection (aeronautics); Chemistry; Computational biology; Nanotechnology; Gene; Biology; Biochemistry; Materials science; Engineering","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001506482,0.0002318993,0.0007134415,0.0002902586,0.00001278613,0.0000066647,0.000209864,0.0007282579,0.0000011524],"category_scores_gemma":[0.000007661605,0.0001658708,0.00008997005,0.0001554771,0.0002863613,0.000003703874,0.0002245069,0.0001092404,4.311273e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000287575,"about_ca_system_score_gemma":0.00002829544,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002192477,"about_ca_topic_score_gemma":0.000007708049,"domain_scores_codex":[0.9990222,0.00003727074,0.0003936053,0.0003211247,0.00004355808,0.0001822566],"domain_scores_gemma":[0.9995099,0.000006436013,0.000168671,0.0002838967,0.00001653585,0.00001452138],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001130382,0.00004081593,0.001683485,0.002686138,0.0002319788,0.000004164337,0.00005156379,0.000005817825,0.1199873,0.000006205801,0.0001646809,0.8750248],"study_design_scores_gemma":[0.001908529,0.002777832,0.00140313,0.006532675,0.00025933,0.0002150229,0.0003369305,0.0004145328,0.7669085,0.00003430562,0.2180107,0.001198579],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.4488085,0.5505974,0.00007842812,0.00001015713,0.0002730795,0.0002027142,0.00002362245,0.000004369897,0.000001818002],"genre_scores_gemma":[0.1588641,0.8405848,0.0004190519,0.000003862961,0.00002369593,0.00002486143,0.00004282052,0.00001857222,0.00001821046],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8738262,"threshold_uncertainty_score":0.6764017,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01084465506242142,"score_gpt":0.2435183166586392,"score_spread":0.2326736615962178,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}