{"id":"W2948179469","doi":"10.3389/fbioe.2019.00131","title":"At the Intersection of Biomaterials and Gene Therapy: Progress in Non-viral Delivery of Nucleic Acids","year":2019,"lang":"en","type":"review","venue":"Frontiers in Bioengineering and Biotechnology","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":62,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Alberta Innovates; Cure Brain Cancer Foundation; University of Alberta","keywords":"Nucleic acid; Genetic enhancement; Gene delivery; Intersection (aeronautics); Chemistry; Computational biology; Nanotechnology; Gene; Biology; Biochemistry; Materials science; Engineering","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005691417,0.0007337319,0.001006693,0.002108042,0.0003199488,0.001280411,0.0005705813,0.001516211,0.002097483],"category_scores_gemma":[0.0005423718,0.0002346118,0.0003628961,0.002330405,0.001005664,0.001984428,0.0007369832,0.002396193,0.001805709],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007190583,"about_ca_system_score_gemma":0.001161554,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006592548,"about_ca_topic_score_gemma":0.0008928112,"domain_scores_codex":[0.9997447,0.00005529871,0.0000252627,0.00004166324,0.0001069692,0.0000260573],"domain_scores_gemma":[0.9997101,0.0001833142,0.00002373738,0.000009658747,0.00004884232,0.00002429138],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007404201,0.0001089988,0.0001694551,0.01632848,0.00005037294,0.0004090078,0.0002150681,0.0005069636,0.01164058,0.02458916,0.01687969,0.9290281],"study_design_scores_gemma":[0.000008485554,0.0001055704,0.0004355277,0.002417678,0.00003692261,0.00135844,0.0001080023,0.0000862153,0.002051128,0.005915519,0.9874581,0.00001858507],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0000913412,0.9982244,0.0002585934,0.0002492543,0.0001999527,0.000002018144,0.000003322464,0.000004774362,0.0009662138],"genre_scores_gemma":[0.0006787056,0.9979872,0.0003027487,0.0002315157,0.0001882906,0.000004154667,0.000006679519,0.000001865444,0.0005988887],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002108042,"threshold_uncertainty_score":0.007016778,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01084465506242142,"score_gpt":0.2435183166586392,"score_spread":0.2326736615962178,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}