{"id":"W2948239232","doi":"10.1021/acsinfecdis.9b00091","title":"Inhibition of Marburg Virus RNA Synthesis by a Synthetic Anti-VP35 Antibody","year":2019,"lang":"en","type":"article","venue":"ACS Infectious Diseases","topic":"Viral Infections and Outbreaks Research","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Argonne National Laboratory; National Institute of General Medical Sciences; National Institutes of Health; Biological and Environmental Research; National Institute of Allergy and Infectious Diseases; Georgia Research Alliance; U.S. Department of Energy","keywords":"Marburg virus; Virology; Ebola virus; Virus; Biology; Ebolavirus; Interferon; Antibody; Filoviridae; Viral replication; RNA; Immunology; Viral disease; Paramyxoviridae; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001382961,0.0002024274,0.0004548423,0.0003011033,0.0001088,0.00003612944,0.00006201511,0.0001162528,0.0007114232],"category_scores_gemma":[0.0003257608,0.0001754566,0.0002244644,0.0004637157,0.0001527487,0.0001784045,0.00007221216,0.0001871118,0.0004772278],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009868852,"about_ca_system_score_gemma":0.0001140819,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005870301,"about_ca_topic_score_gemma":0.000008026243,"domain_scores_codex":[0.9985113,0.00009426018,0.0003186743,0.0003432908,0.0003947651,0.0003377081],"domain_scores_gemma":[0.9988458,0.0002243904,0.0001156726,0.0004174312,0.0001903851,0.0002063741],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001458289,0.001641513,0.2983496,0.0004868319,0.0002198741,0.00003553508,0.00003021623,0.00002124128,0.6883084,0.0001728433,0.003157049,0.007431129],"study_design_scores_gemma":[0.002695757,0.00158198,0.210909,0.0009852379,0.0008221344,0.0001946256,0.000146407,0.0003630884,0.7769035,0.0004237144,0.004347258,0.0006272844],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.991525,0.0005862897,0.000111004,0.0001253299,0.0001653549,0.000552626,0.0002016441,0.0003401046,0.006392629],"genre_scores_gemma":[0.9985304,0.0006604801,0.000006703965,0.0001467137,0.0000892323,0.00005583457,0.00005958583,0.0000686832,0.0003823609],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08859512,"threshold_uncertainty_score":0.7789586,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00891405647748575,"score_gpt":0.2920548299779642,"score_spread":0.2831407735004784,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}