{"id":"W2948262853","doi":"10.2337/db18-1367","title":"Unconventional Secretion of Adipocyte Fatty Acid Binding Protein 4 Is Mediated By Autophagic Proteins in a Sirtuin-1–Dependent Manner","year":2019,"lang":"en","type":"article","venue":"Diabetes","topic":"Peroxisome Proliferator-Activated Receptors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; American Diabetes Association; National Institute of General Medical Sciences; National Institute on Aging; Minnesota Agricultural Experiment Station; National Institutes of Health","keywords":"Secretion; Autophagy; Sirtuin; ATG5; Fatty acid-binding protein; Endocrinology; Sirtuin 1; SIRT2; Internal medicine; Gene knockdown; Adipocyte; Resveratrol; Adipose tissue; Biology; Cell biology; Chemistry; Downregulation and upregulation; Biochemistry; Medicine; Apoptosis; Acetylation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002282985,0.0004722767,0.0003080965,0.000298322,0.0001748497,0.0003396219,0.0002338291,0.0002645782,0.001127764],"category_scores_gemma":[0.0001055417,0.0001982481,0.000499894,0.0001998377,0.0002929832,0.0003439331,0.0002671836,0.0004231367,0.0005457157],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004653446,"about_ca_system_score_gemma":0.0002273308,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004098616,"about_ca_topic_score_gemma":0.0006493667,"domain_scores_codex":[0.9998259,0.00003726091,0.0000162765,0.00004361168,0.00004345462,0.00003339461],"domain_scores_gemma":[0.9999175,0.000007709329,0.00002933903,0.00001400994,0.00001478847,0.0000166428],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001607484,0.00001596355,0.0002219634,0.00004394122,0.000009886978,0.00006924861,0.000007299885,0.00003572696,0.9982982,0.0001747229,0.0000440667,0.0009181544],"study_design_scores_gemma":[0.00004224116,0.0001676702,0.01184907,0.000007444484,0.0000280942,0.0004257501,0.00002063946,0.001333623,0.982178,0.0001355245,0.003802715,0.000009277834],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.978311,0.005830138,0.01150179,0.0003778568,0.0001457242,0.00004715159,0.0006037648,0.0002873403,0.002895168],"genre_scores_gemma":[0.9853994,0.002572296,0.004627567,0.000153116,0.00002658137,0.00005540688,0.000828994,0.00004685516,0.006289884],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001127764,"threshold_uncertainty_score":0.003772676,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005571973910430838,"score_gpt":0.2129289070678042,"score_spread":0.2073569331573733,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}