{"id":"W2948262853","doi":"10.2337/db18-1367","title":"Unconventional Secretion of Adipocyte Fatty Acid Binding Protein 4 Is Mediated By Autophagic Proteins in a Sirtuin-1–Dependent Manner","year":2019,"lang":"en","type":"article","venue":"Diabetes","topic":"Peroxisome Proliferator-Activated Receptors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; American Diabetes Association; National Institute of General Medical Sciences; National Institute on Aging; Minnesota Agricultural Experiment Station; National Institutes of Health","keywords":"Secretion; Autophagy; Sirtuin; ATG5; Fatty acid-binding protein; Endocrinology; Sirtuin 1; SIRT2; Internal medicine; Gene knockdown; Adipocyte; Resveratrol; Adipose tissue; Biology; Cell biology; Chemistry; Downregulation and upregulation; Biochemistry; Medicine; Apoptosis; Acetylation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002272663,0.0001970067,0.0002287801,0.000115756,0.00002756368,0.00001682332,0.0001822814,0.000256073,0.0003670638],"category_scores_gemma":[0.00006922679,0.0001887085,0.00008975995,0.0001823197,0.00005545124,0.00001473041,0.00008988623,0.000158119,0.00007846303],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005075966,"about_ca_system_score_gemma":0.00007835734,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001121945,"about_ca_topic_score_gemma":0.000002917253,"domain_scores_codex":[0.9986139,0.00009958503,0.0003083136,0.0004077077,0.0002480243,0.0003225051],"domain_scores_gemma":[0.9994341,0.000007534245,0.0001673839,0.000241681,0.00007468155,0.00007457795],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003628243,0.000114125,0.05026698,0.00007907434,0.00007468017,5.143853e-7,0.00003241356,0.000006863819,0.9490914,0.00001258213,0.0001289191,0.0001562049],"study_design_scores_gemma":[0.0009420235,0.0002581842,0.001102193,0.00008230745,0.000007260747,4.628407e-7,0.00002765822,0.0001537392,0.9965363,0.00003430741,0.0006422075,0.0002133313],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981389,0.0005227464,0.0000260992,0.00008571937,0.0001082997,0.0007852296,0.0001607465,0.00001841828,0.0001538315],"genre_scores_gemma":[0.9982012,0.00001745367,0.0001369535,0.00007255506,0.00003996529,0.0001821031,0.0006830788,0.00003003394,0.0006366791],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04916479,"threshold_uncertainty_score":0.7695311,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005571973910430838,"score_gpt":0.2129289070678042,"score_spread":0.2073569331573733,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}