{"id":"W2948296075","doi":"10.1038/s41467-019-10217-w","title":"Aβ-induced vulnerability propagates via the brain’s default mode network","year":2019,"lang":"en","type":"article","venue":"Nature Communications","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":91,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; McGill University; Montreal Neurological Institute and Hospital","funders":"Engineering and Physical Sciences Research Council; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Institute on Aging; Alzheimer Society Research Program; University of California, San Diego; Genentech; National Institutes of Health; IXICO; H. Lundbeck A/S; Servier; Eisai; Government of Canada; Weston Brain Institute; Northern California Institute for Research and Education; Pfizer; Biogen; BioClinica; F. Hoffmann-La Roche; University of Southern California; Eli Lilly and Company; U.S. Department of Defense; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; Novartis Pharmaceuticals Corporation; Alzheimer Society; Bristol-Myers Squibb; Consortium canadien en neurodégénérescence associée au vieillissement; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Default mode network; Dementia; Positron emission tomography; Cognitive decline; Neuroscience; Vulnerability (computing); Mechanism (biology); Cognition; Genetically modified mouse; Disease; Amyloid (mycology); Psychology; Medicine; Biology; Transgene; Internal medicine; Computer science; Pathology; Physics; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002281133,0.0002069343,0.0002150173,0.0002987572,0.0001808283,0.0004145461,0.0002718048,0.0002755441,0.0009305962],"category_scores_gemma":[0.0004718886,0.0001118172,0.0001985894,0.0001142844,0.0002999259,0.0006307629,0.0002815585,0.0003433602,0.0001416613],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003439124,"about_ca_system_score_gemma":0.0001562339,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006146356,"about_ca_topic_score_gemma":0.0006337418,"domain_scores_codex":[0.9999412,0.00001595552,0.000002522061,0.00001630115,0.00001219029,0.00001187579],"domain_scores_gemma":[0.9997848,0.00004912257,0.0000646738,0.00003122372,0.00003301464,0.00003718477],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007874987,0.0002087128,0.04561347,0.0001984813,0.000263192,0.001915334,0.0004328297,0.01396806,0.8291878,0.03219305,0.002404739,0.07282677],"study_design_scores_gemma":[0.0003003849,0.001559465,0.3312885,0.0001705661,0.0003310985,0.008667834,0.0006928109,0.2500451,0.2034957,0.1937294,0.009573508,0.0001457177],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9367561,0.0009623484,0.05771093,0.0004011594,0.00003102932,0.00001996766,0.0001639251,0.0002067447,0.003747746],"genre_scores_gemma":[0.9961357,0.0002100177,0.003178396,0.00002814202,0.000008823878,0.00001017281,0.00002853927,0.000003660447,0.0003966471],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009305962,"threshold_uncertainty_score":0.00311321,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03543639838087007,"score_gpt":0.3727750887783768,"score_spread":0.3373386903975067,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}