{"id":"W2948309692","doi":"10.1038/s41467-019-10335-5","title":"Senescent cells evade immune clearance via HLA-E-mediated NK and CD8+ T cell inhibition","year":2019,"lang":"en","type":"article","venue":"Nature Communications","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":533,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Institute of Genetics; National Institute on Aging; National Institutes of Health; University College London; Medical Research Council; Barts Charity; Biotechnology and Biological Sciences Research Council; Foundation for the National Institutes of Health; Buck Institute for Research on Aging; National Institute for Health and Care Research","keywords":"Cytotoxic T cell; Immune system; Immunology; Cell biology; CD8; Human leukocyte antigen; T cell; Biology; Chemistry; Antigen; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001989803,0.0001763226,0.0002112307,0.000129806,0.0003162505,0.00002719737,0.0003266111,0.0005668969,0.0006976518],"category_scores_gemma":[0.00003594643,0.0001724263,0.00008441098,0.0002065813,0.0001485537,0.0002036489,0.00023276,0.001509106,0.003420404],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007133935,"about_ca_system_score_gemma":0.00003301035,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005617485,"about_ca_topic_score_gemma":0.00002953203,"domain_scores_codex":[0.9988684,0.0002868622,0.0003223865,0.0002500921,0.00004414759,0.0002281109],"domain_scores_gemma":[0.9982396,0.0002260865,0.0001837545,0.001170747,0.0001568276,0.00002295343],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009395697,0.0001952169,0.0005156893,0.00002085492,0.00003528013,2.431722e-7,0.0002087063,0.00000351074,0.9904336,0.0003469206,0.007434548,0.0007115081],"study_design_scores_gemma":[0.001466135,0.0001225835,0.01037054,0.00007051115,0.00004006151,0.00003670665,0.0003264322,0.0002051317,0.4621075,0.00002695516,0.5249561,0.000271351],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.891115,0.07420714,0.0002317015,0.004393847,0.007801863,0.001192637,0.00003664317,0.0003806281,0.02064057],"genre_scores_gemma":[0.987549,0.003303123,0.000167972,0.0007919701,0.00001799061,0.00002316215,0.0007513477,0.00002272794,0.007372687],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.528326,"threshold_uncertainty_score":0.9973555,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006675919637551439,"score_gpt":0.2302248828398882,"score_spread":0.2235489632023368,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}