{"id":"W2948322013","doi":"10.1161/circ.132.suppl_3.17701","title":"Abstract 17701: Nrf2 Inhibits NF-κB Activation During Ischemia Reperfusion Injury and Suppresses Subsequent Development of Cardiac Allograft Vasculopathy in Murine Heart Transplantation","year":2015,"lang":"en","type":"article","venue":"Circulation","topic":"Cancer-related molecular mechanisms research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network","funders":"","keywords":"Medicine; Transplantation; Reperfusion injury; Sulforaphane; Heart transplantation; Saline; NF-κB; Ischemia; Proinflammatory cytokine; Agonist; Pharmacology; Internal medicine; Endocrinology; Inflammation; Receptor; Cancer research","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002844979,0.0008064317,0.0007147891,0.0004019733,0.0002491068,0.0002964863,0.0003354915,0.0004529497,0.005573761],"category_scores_gemma":[0.0001134775,0.0001967052,0.0004135141,0.0002217035,0.000455391,0.0004055661,0.0002366204,0.001189819,0.001213603],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002186532,"about_ca_system_score_gemma":0.0004502143,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002433166,"about_ca_topic_score_gemma":0.000497747,"domain_scores_codex":[0.9998136,0.00003079012,0.00002629621,0.00002695482,0.00004821001,0.00005413243],"domain_scores_gemma":[0.9998962,0.000006901704,0.00002908409,0.00001358359,0.00001094016,0.00004323251],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002206968,0.000828368,0.0001625353,0.0002922433,0.00002997756,0.0001059992,0.00003449462,0.0001019408,0.9920037,0.0002009866,0.0005660098,0.003466766],"study_design_scores_gemma":[0.0006134043,0.008557304,0.002511341,0.00004909877,0.00005811399,0.0004575601,0.00007260647,0.0005841936,0.9812776,0.0001238627,0.005680683,0.00001422943],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9862087,0.003929697,0.002888023,0.0005176816,0.0003108528,0.0001731794,0.001492949,0.0004217764,0.004057167],"genre_scores_gemma":[0.980581,0.002666684,0.003437198,0.0002792118,0.00007827258,0.0003867978,0.002418217,0.00005629746,0.01009615],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005573761,"threshold_uncertainty_score":0.01864606,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01534575141133871,"score_gpt":0.2643880892250162,"score_spread":0.2490423378136775,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}