{"id":"W2948351213","doi":"10.1038/s41467-019-10144-w","title":"Activated Peyer′s patch B cells sample antigen directly from M cells in the subepithelial dome","year":2019,"lang":"en","type":"article","venue":"Nature Communications","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":92,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Biotechnology and Biological Sciences Research Council; Directorate for Biological Sciences; Göteborgs Universitet; Swedish Cancer Foundation; Azrieli Foundation; Vetenskapsrådet; Rising Tide Foundation; Stiftelsen för Strategisk Forskning","keywords":"Antigen; Germinal center; Microfold cell; Antigen-presenting cell; B cell; CD40; Chemistry; Naive B cell; B-cell receptor; Cell biology; T cell; Peyer's patch; Molecular biology; Biology; Antibody; Immunology; Cytotoxic T cell; Immune system; In vitro; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008944772,0.0002211189,0.0001938082,0.0001764871,0.0001421411,0.0002860454,0.0001299491,0.0003436507,0.002195257],"category_scores_gemma":[0.00008604609,0.0001424331,0.0001677629,0.00006027283,0.0001766885,0.0003210923,0.0002437612,0.0005497686,0.001008973],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001137053,"about_ca_system_score_gemma":0.00006921167,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001872665,"about_ca_topic_score_gemma":0.0002030642,"domain_scores_codex":[0.9999082,0.00001210179,0.000003796767,0.00003062838,0.00001664544,0.00002852848],"domain_scores_gemma":[0.999889,0.0000235111,0.00002440945,0.00001473821,0.00001096274,0.00003730942],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004160074,0.000003793262,0.000277101,0.00001519714,0.000001025793,0.00002790061,0.000007913236,0.000006253399,0.999049,0.00003365719,0.00001447213,0.0005219906],"study_design_scores_gemma":[0.00001395503,0.000227926,0.02393899,0.00001207958,0.00001007838,0.0005592131,0.00008987424,0.0004597633,0.972338,0.0001143699,0.002231878,0.000003865467],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9910341,0.001179332,0.005542976,0.00006655137,0.00002526106,0.00001378275,0.0001053933,0.00009067738,0.001941888],"genre_scores_gemma":[0.9934006,0.0004261579,0.003484694,0.00007760159,0.00001950879,0.00001531806,0.0001532677,0.00002692957,0.002395906],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002195257,"threshold_uncertainty_score":0.007343888,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01249047715748618,"score_gpt":0.2506604486745707,"score_spread":0.2381699715170845,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}