{"id":"W2948351213","doi":"10.1038/s41467-019-10144-w","title":"Activated Peyer′s patch B cells sample antigen directly from M cells in the subepithelial dome","year":2019,"lang":"en","type":"article","venue":"Nature Communications","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":92,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Biotechnology and Biological Sciences Research Council; Directorate for Biological Sciences; Göteborgs Universitet; Swedish Cancer Foundation; Azrieli Foundation; Vetenskapsrådet; Rising Tide Foundation; Stiftelsen för Strategisk Forskning","keywords":"Antigen; Germinal center; Microfold cell; Antigen-presenting cell; B cell; CD40; Chemistry; Naive B cell; B-cell receptor; Cell biology; T cell; Peyer's patch; Molecular biology; Biology; Antibody; Immunology; Cytotoxic T cell; Immune system; In vitro; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["research_integrity","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0003680304,0.000254055,0.0003663669,0.0001389763,0.0003555486,0.00003641397,0.002600917,0.000936824,0.0007803876],"category_scores_gemma":[0.00007511384,0.0001877954,0.0001389886,0.0004382307,0.0003127234,0.0001115572,0.0004685844,0.002472296,0.002200515],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005314821,"about_ca_system_score_gemma":0.00008168121,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003572874,"about_ca_topic_score_gemma":0.002068308,"domain_scores_codex":[0.9977152,0.001049389,0.0003752997,0.0003623819,0.00006187318,0.0004357957],"domain_scores_gemma":[0.9946132,0.002371847,0.0001733574,0.002738398,0.00008563067,0.00001760802],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007154451,0.0003927268,0.004150321,0.000003047769,0.0001061228,0.000001194991,0.001322718,0.000004516023,0.9877905,0.000725076,0.004574473,0.0008577206],"study_design_scores_gemma":[0.001052196,0.00005550497,0.005359452,0.00001911723,0.00002841411,0.000005147891,0.0006131354,0.00001305411,0.6437603,0.0004247277,0.348444,0.0002249572],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9820274,0.01013149,0.00001378207,0.002599889,0.001323674,0.0005947121,0.0004527453,0.0001019869,0.002754312],"genre_scores_gemma":[0.9943439,0.002052757,0.0005495637,0.000807863,0.00002941574,0.00004672744,0.001167671,0.00002662119,0.0009754188],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3440302,"threshold_uncertainty_score":0.9998291,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01249047715748618,"score_gpt":0.2506604486745707,"score_spread":0.2381699715170845,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}