{"id":"W2948421871","doi":"10.1007/s40263-019-00643-1","title":"Endolysosome and Autolysosome Dysfunction in Alzheimer’s Disease: Where Intracellular and Extracellular Meet","year":2019,"lang":"en","type":"review","venue":"CNS Drugs","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Alzheimer Nederland; ZonMw; EU Joint Programme – Neurodegenerative Disease Research; Weston Brain Institute; Alzheimer's Association","keywords":"Proteostasis; Intracellular; Lysosome; Endosome; Autophagy; Extracellular; Cell biology; Neuroscience; Disease; Biology; Secretion; Medicine; Pathology; Genetics; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002540617,0.00071841,0.001092852,0.002250116,0.0002918221,0.0008411451,0.0005163638,0.0009810032,0.003108665],"category_scores_gemma":[0.0003125398,0.0001668721,0.0004054781,0.002428974,0.000384197,0.001146671,0.0006432897,0.001164285,0.001843965],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005140346,"about_ca_system_score_gemma":0.0009512219,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008549226,"about_ca_topic_score_gemma":0.001750312,"domain_scores_codex":[0.9998807,0.00002034418,0.00001870648,0.00001819208,0.00004797026,0.00001417153],"domain_scores_gemma":[0.99989,0.00003855356,0.00002321369,0.00000397247,0.00003028641,0.00001392603],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008240835,0.00005974674,0.0001984302,0.02358519,0.00009690622,0.0003686586,0.0001044615,0.0002789035,0.003107352,0.005528767,0.03328123,0.9333079],"study_design_scores_gemma":[0.00001074797,0.00007904353,0.001181467,0.005225016,0.00009496383,0.002434959,0.00009474221,0.00006575073,0.0004942311,0.002886804,0.987417,0.0000152282],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00009638521,0.9985328,0.0000700738,0.0001465679,0.0001491513,0.000002559468,0.0000114094,0.000005511232,0.0009854147],"genre_scores_gemma":[0.000642627,0.9983082,0.000118685,0.0001245379,0.00008395195,0.000003394828,0.0000242761,0.000001006399,0.0006932166],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003108665,"threshold_uncertainty_score":0.01039946,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03713491956147538,"score_gpt":0.3097020473000599,"score_spread":0.2725671277385845,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}