{"id":"W2948421871","doi":"10.1007/s40263-019-00643-1","title":"Endolysosome and Autolysosome Dysfunction in Alzheimer’s Disease: Where Intracellular and Extracellular Meet","year":2019,"lang":"en","type":"review","venue":"CNS Drugs","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Alzheimer Nederland; ZonMw; EU Joint Programme – Neurodegenerative Disease Research; Weston Brain Institute; Alzheimer's Association","keywords":"Proteostasis; Intracellular; Lysosome; Endosome; Autophagy; Extracellular; Cell biology; Neuroscience; Disease; Biology; Secretion; Medicine; Pathology; Genetics; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003186602,0.0007117265,0.002131891,0.0004336358,0.00007921441,0.00006872325,0.0001576958,0.0004844538,0.0003277826],"category_scores_gemma":[0.00003607348,0.000594845,0.0003683173,0.0003346387,0.0001845677,0.0001857682,0.0001148114,0.0005897317,0.0001473278],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000111717,"about_ca_system_score_gemma":0.0004469259,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002010038,"about_ca_topic_score_gemma":0.00000231983,"domain_scores_codex":[0.9972195,0.0002013966,0.0007478679,0.0009424053,0.0003826744,0.0005061696],"domain_scores_gemma":[0.9981218,0.0001727085,0.0002987199,0.0008058509,0.0000412702,0.0005596571],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001196306,0.0002504617,0.0002281659,0.02097362,0.0007964628,0.0007102935,0.0002691356,5.778097e-7,0.00002595345,0.001217137,0.0006058523,0.9748027],"study_design_scores_gemma":[0.001726389,0.0001118005,0.0002933154,0.0123875,0.005685807,0.0001326287,0.00005118487,0.00009892493,0.00001110828,0.000253106,0.9786174,0.0006308375],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.002426822,0.994448,0.00001212763,0.0001649486,0.0003805371,0.001992093,0.00007636422,0.0001117977,0.0003872854],"genre_scores_gemma":[0.001946269,0.9947842,0.00005129265,0.00009057022,0.0003655548,0.0001771943,0.000300536,0.0001428567,0.002141479],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9780115,"threshold_uncertainty_score":0.9996503,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03713491956147538,"score_gpt":0.3097020473000599,"score_spread":0.2725671277385845,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}