{"id":"W2948506494","doi":"10.1002/bab.1789","title":"Deletion of <i>arcA</i>, <i>iclR</i>, and <i>tdcC</i> in <i>Escherichia coli</i> to improve <scp>l</scp>‐threonine production","year":2019,"lang":"en","type":"article","venue":"Biotechnology and Applied Biochemistry","topic":"Microbial Metabolic Engineering and Bioproduction","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Key Research and Development Program of China; Institute for Catastrophic Loss Reduction; Dow Chemical Company","keywords":"Escherichia coli; Threonine; Production (economics); Biology; Microbiology; Biochemistry; Gene; Enzyme; Economics; Serine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001455633,0.000641838,0.0003121304,0.0002745512,0.0001291629,0.0003943456,0.0004644569,0.0003058521,0.0007950629],"category_scores_gemma":[0.0001927236,0.0002173835,0.0004793575,0.0003348495,0.000227411,0.0001548242,0.0002897365,0.0007036679,0.0004036248],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004455373,"about_ca_system_score_gemma":0.0004153342,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002670338,"about_ca_topic_score_gemma":0.002942828,"domain_scores_codex":[0.9997098,0.000037511,0.00005269848,0.00004857701,0.00008773064,0.00006366138],"domain_scores_gemma":[0.9998313,0.000023757,0.00005980847,0.00002639136,0.00002209089,0.00003658826],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004909932,0.00003115138,0.0002045262,0.00001917509,0.000004251755,0.00003701562,0.000008879682,0.00003993223,0.998877,0.00003250383,0.00002061586,0.0006758632],"study_design_scores_gemma":[0.00001290606,0.0001372234,0.004358246,0.000007976423,0.00002624631,0.0002322549,0.00004948711,0.0007305519,0.9927603,0.00001119843,0.001665525,0.000008009315],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944977,0.0002433146,0.003339004,0.00006025826,0.00002790301,0.00005234829,0.0006023617,0.0001037399,0.001073499],"genre_scores_gemma":[0.9848657,0.0003436971,0.009190267,0.00006742993,0.00000733254,0.00006773795,0.002193108,0.0001007262,0.003164063],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002670338,"threshold_uncertainty_score":0.005309582,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00210799405959034,"score_gpt":0.1767740602620275,"score_spread":0.1746660662024372,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}