{"id":"W2948506494","doi":"10.1002/bab.1789","title":"Deletion of <i>arcA</i>, <i>iclR</i>, and <i>tdcC</i> in <i>Escherichia coli</i> to improve <scp>l</scp>‐threonine production","year":2019,"lang":"en","type":"article","venue":"Biotechnology and Applied Biochemistry","topic":"Microbial Metabolic Engineering and Bioproduction","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Key Research and Development Program of China; Institute for Catastrophic Loss Reduction; Dow Chemical Company","keywords":"Escherichia coli; Threonine; Production (economics); Biology; Microbiology; Biochemistry; Gene; Enzyme; Economics; Serine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002055665,0.0002168433,0.0002592932,0.00008023295,0.00003505725,0.000009234567,0.0001232827,0.00055822,0.000001950119],"category_scores_gemma":[0.00009912034,0.0002200445,0.00002960096,0.0002757217,0.0001470464,0.000004232522,0.0001482447,0.0002131243,0.000005231736],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001099184,"about_ca_system_score_gemma":0.00002786398,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007911747,"about_ca_topic_score_gemma":0.000004878449,"domain_scores_codex":[0.9987265,0.00000971007,0.000258214,0.0006703538,0.00007299949,0.0002621559],"domain_scores_gemma":[0.9994195,0.000005248768,0.00009706562,0.0003782325,0.0000381571,0.0000618116],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005100985,0.00005857496,0.0003549329,0.0001545899,0.00002013513,2.775865e-7,0.00002438014,0.00002819267,0.9968513,0.0002090988,0.000563578,0.00168396],"study_design_scores_gemma":[0.0004673736,0.0001124423,0.0003165359,0.00002734751,0.00001413277,0.00001862517,0.0001512953,0.000005475623,0.982725,0.00004526453,0.01599153,0.0001249808],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973775,0.001081519,0.0001218264,0.000426833,0.000181008,0.000389993,0.00001647863,0.00004191261,0.0003629441],"genre_scores_gemma":[0.9970459,0.0005953437,0.001457448,0.000149153,0.0001607007,0.00003712051,0.00004739758,0.00002103745,0.0004858674],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01542795,"threshold_uncertainty_score":0.8973155,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00210799405959034,"score_gpt":0.1767740602620275,"score_spread":0.1746660662024372,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}