{"id":"W2948582879","doi":"10.1093/nar/gkz269","title":"Structural insights into the modulatory role of the accessory protein WYL1 in the Type VI-D CRISPR-Cas system","year":2019,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; Structural Genomics Consortium; University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Wellcome Trust","keywords":"Biology; CRISPR; Effector; RNA; RNase P; Computational biology; Cell biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001316712,0.0002702377,0.0002286525,0.00008807342,0.0001869946,0.0003611479,0.000297335,0.0003501419,0.0009675255],"category_scores_gemma":[0.00009635834,0.000164636,0.0002123436,0.00005699117,0.0002707152,0.0003311927,0.0002251483,0.0006308721,0.0003595336],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004637752,"about_ca_system_score_gemma":0.0002918588,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004984544,"about_ca_topic_score_gemma":0.0005245333,"domain_scores_codex":[0.9999527,0.000006430716,0.000004830824,0.00001264002,0.00001186162,0.00001142175],"domain_scores_gemma":[0.9999549,0.000006837256,0.00001104257,0.000004022786,0.000003720605,0.00001937172],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001049331,0.00001981257,0.0005202346,0.0000569805,0.000006500923,0.0003040129,0.00002381425,0.001350948,0.9944602,0.0012701,0.00006495757,0.001817471],"study_design_scores_gemma":[0.00006166394,0.0002772752,0.005482454,0.00002354388,0.00003070938,0.0008990885,0.0001231171,0.04868726,0.9362096,0.001161731,0.007007723,0.00003593606],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9793385,0.001338626,0.01609579,0.0003290326,0.00003952532,0.00003012212,0.0001703562,0.0002021757,0.002455891],"genre_scores_gemma":[0.9912676,0.0007602518,0.006899036,0.00009206731,0.000007460614,0.00001151344,0.0001037295,0.00001297056,0.0008453404],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009675255,"threshold_uncertainty_score":0.003364921,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0162793713809626,"score_gpt":0.3311758770190848,"score_spread":0.3148965056381222,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}