{"id":"W2948582879","doi":"10.1093/nar/gkz269","title":"Structural insights into the modulatory role of the accessory protein WYL1 in the Type VI-D CRISPR-Cas system","year":2019,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; Structural Genomics Consortium; University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Wellcome Trust","keywords":"Biology; CRISPR; Effector; RNA; RNase P; Computational biology; Cell biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007257716,0.0001150829,0.0001157755,0.00005397479,0.0001445845,0.00003938604,0.001026351,0.0001334264,0.00001863564],"category_scores_gemma":[0.0000979835,0.00005737668,0.00006611064,0.0003454738,0.0001559778,0.000005806573,0.0003924144,0.0003942779,0.00001997774],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000393907,"about_ca_system_score_gemma":0.00009859056,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001810668,"about_ca_topic_score_gemma":0.0001112451,"domain_scores_codex":[0.9984466,0.0003248762,0.000189364,0.0002504385,0.000479501,0.0003091664],"domain_scores_gemma":[0.9988591,0.00003577193,0.0000372699,0.0008833064,0.0001497628,0.00003477329],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004897981,0.00001433489,0.005929932,0.00009583776,0.0000236417,0.000001151827,0.002386485,0.0006452541,0.9880407,0.001138599,0.0001487119,0.001526384],"study_design_scores_gemma":[0.0005046537,0.0002881383,0.1153573,0.0000992386,0.000008658107,0.00001139642,0.007848626,0.006913717,0.8553722,0.0004345494,0.01295459,0.000206895],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948604,0.002164351,0.00001999288,0.0001718481,0.0001180418,0.0007119522,0.000001492075,0.00000590047,0.001946002],"genre_scores_gemma":[0.9993852,0.00002751541,0.00003057047,0.00003199902,0.0001241365,0.00003649983,0.000003535848,0.00002030802,0.000340174],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1326685,"threshold_uncertainty_score":0.2339753,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0162793713809626,"score_gpt":0.3311758770190848,"score_spread":0.3148965056381222,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}