{"id":"W2948651404","doi":"10.1186/s13195-019-0508-x","title":"Upregulation of MIF as a defense mechanism and a biomarker of Alzheimer’s disease","year":2019,"lang":"en","type":"article","venue":"Alzheimer s Research & Therapy","topic":"Macrophage Migration Inhibitory Factor","field":"Immunology and Microbiology","cited_by":76,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia Hospital; University of British Columbia","funders":"Canadian Institutes of Health Research; Michael Smith Health Research BC","keywords":"Downregulation and upregulation; Biomarker; Mechanism (biology); Disease; Alzheimer's disease; Medicine; Chemistry; Internal medicine; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0007990581,0.0001666722,0.0003014292,0.0003059635,0.00009973399,0.0000137465,0.0002047687,0.0001744392,0.00323619],"category_scores_gemma":[0.0000645439,0.000141362,0.0001090484,0.0002934792,0.0004190928,0.00013479,0.0001008269,0.00021578,0.0003408894],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009220925,"about_ca_system_score_gemma":0.0001588033,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002757357,"about_ca_topic_score_gemma":0.000007513583,"domain_scores_codex":[0.9979904,0.0007302233,0.0003758539,0.0003629545,0.000189696,0.0003508675],"domain_scores_gemma":[0.9985729,0.0003058467,0.0001479081,0.0005340587,0.0003704038,0.00006880936],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001428419,0.0001780935,0.002364411,0.00001502736,0.001104232,0.000002706836,0.0009676088,9.811733e-7,0.9777378,0.005932227,0.0009043117,0.009364194],"study_design_scores_gemma":[0.002873444,0.0007220603,0.02773467,0.00005565477,0.0001181079,0.00001028543,0.0003009671,0.0000501061,0.9523678,0.004821435,0.01072001,0.0002254507],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9441921,0.05380898,0.00003668703,0.0002389943,0.0002067261,0.001044203,0.00005157262,0.00002491147,0.0003958627],"genre_scores_gemma":[0.9986358,0.0005539706,0.00007281725,0.00005198361,0.00001472351,0.00004861202,0.00007542067,0.00002678591,0.0005198338],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05444379,"threshold_uncertainty_score":0.997675,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08054573646689787,"score_gpt":0.3511382838632003,"score_spread":0.2705925473963024,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}