{"id":"W2948656131","doi":"10.1101/657163","title":"Familial t(1;11) translocation is associated with disruption of white matter structural integrity and oligodendrocyte-myelin dysfunction","year":2019,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Discovery Centre","funders":"Medical Research Council; Wellcome Trust; Pfizer","keywords":"Oligodendrocyte; Myelin; White matter; Chromosomal translocation; Biology; Cell biology; Neuroscience; Induced pluripotent stem cell; Genetics; Central nervous system; Medicine; Gene; Embryonic stem cell; Magnetic resonance imaging","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001347465,0.0003589028,0.0002361673,0.0004009492,0.0002312578,0.0002546022,0.00008835329,0.0004952389,0.00450293],"category_scores_gemma":[0.0002596494,0.0001175899,0.0001692424,0.0003091189,0.000369504,0.00009600999,0.0003616552,0.0003893195,0.0005702991],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000150129,"about_ca_system_score_gemma":0.0001341208,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004332237,"about_ca_topic_score_gemma":0.0003692651,"domain_scores_codex":[0.9998783,0.00001984005,0.0000138373,0.0000406402,0.00002839669,0.00001900473],"domain_scores_gemma":[0.9998606,0.00002878923,0.00006510176,0.0000128338,0.000007840076,0.0000247374],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.000359155,0.00006668487,0.01289552,0.00008827413,0.000049046,0.02290714,0.0002253965,0.0004083503,0.9543874,0.00106881,0.0007624652,0.006781839],"study_design_scores_gemma":[0.0001181371,0.0006447083,0.1794637,0.00006336963,0.0001752796,0.188409,0.0006290182,0.003236515,0.6056268,0.003218472,0.0183691,0.00004598839],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939716,0.0005915471,0.003070373,0.000279924,0.00005431731,0.00001081713,0.0005596832,0.0000818611,0.001379811],"genre_scores_gemma":[0.9965654,0.0004176378,0.001173806,0.00003808963,0.00002655347,0.000005472005,0.0003470577,0.00001983172,0.00140607],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00450293,"threshold_uncertainty_score":0.01506376,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008037690315791277,"score_gpt":0.2048944985742079,"score_spread":0.1968568082584166,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}