{"id":"W2948662515","doi":"10.1186/s40425-019-0623-z","title":"Final analyses of OPTiM: a randomized phase III trial of talimogene laherparepvec versus granulocyte-macrophage colony-stimulating factor in unresectable stage III–IV melanoma","year":2019,"lang":"en","type":"article","venue":"Journal for ImmunoTherapy of Cancer","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":438,"is_retracted":false,"has_abstract":true,"ca_institutions":"Amgen (Canada); Royal Ottawa Mental Health Centre","funders":"National Institute for Health and Care Research; Amgen","keywords":"Medicine; Oncolytic virus; Internal medicine; Melanoma; Confidence interval; Oncology; Hazard ratio; Randomized controlled trial; Cancer; Cancer research","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001726935,0.0004006584,0.002446265,0.0005538135,0.0001603224,0.00002274657,0.0005281803,0.0003527034,0.004294336],"category_scores_gemma":[0.0002529995,0.0003217862,0.001070314,0.0003948523,0.000411356,0.0002560456,0.00004228513,0.0004712004,0.00000381763],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001644073,"about_ca_system_score_gemma":0.000574991,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002262688,"about_ca_topic_score_gemma":0.00006267701,"domain_scores_codex":[0.9959338,0.0008223486,0.002187099,0.0003030399,0.0001977521,0.0005559775],"domain_scores_gemma":[0.9947825,0.002099431,0.002236445,0.0004556108,0.000398624,0.00002736257],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.500325,0.0004392762,0.0001172506,0.00005329077,0.00202644,0.000001829992,0.0007444554,0.000914911,0.4908683,0.00002089162,0.00003223633,0.004456184],"study_design_scores_gemma":[0.55701,0.003909777,0.0001250414,0.0001904849,0.0001287615,0.000007187029,0.0002389946,0.0001423824,0.4360845,0.00001983117,0.001942359,0.0002006585],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9431677,0.0515602,0.0004727539,0.00003710658,0.002311246,0.002041004,0.0002632214,0.00001264814,0.0001340979],"genre_scores_gemma":[0.9898018,0.005408275,0.0002952219,0.0000274424,0.0000530009,0.0001265577,0.00003024683,0.00005522625,0.004202242],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05668505,"threshold_uncertainty_score":0.9999234,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05177845107064362,"score_gpt":0.3877663574224503,"score_spread":0.3359879063518067,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}