{"id":"W2948668990","doi":"10.1161/circulationaha.118.038571","title":"Caveolin-1 Regulates Atherogenesis by Attenuating Low-Density Lipoprotein Transcytosis and Vascular Inflammation Independently of Endothelial Nitric Oxide Synthase Activation","year":2019,"lang":"en","type":"article","venue":"Circulation","topic":"Caveolin-1 and cellular processes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":158,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute","keywords":"Caveolae; Enos; Caveolin 1; Inflammation; Cell biology; Medicine; Nitric Oxide Synthase Type III; Transcytosis; Caveolin; Nitric oxide; Nitric oxide synthase; Lipoprotein; Endothelium; Endocrinology; Internal medicine; Biology; Cholesterol; Signal transduction; Receptor; Endocytosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002531862,0.0001568142,0.0001811736,0.00007498656,0.00007019494,0.00002439777,0.00007623273,0.0002068933,0.00001550623],"category_scores_gemma":[0.00008360208,0.0001705713,0.00009408656,0.0001331241,0.00003675564,0.00002533286,0.00002843066,0.00006269781,0.000006584288],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002294322,"about_ca_system_score_gemma":0.00004356064,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001730326,"about_ca_topic_score_gemma":0.00001379371,"domain_scores_codex":[0.9989133,0.00006485736,0.0003016225,0.0003395124,0.0002310275,0.000149692],"domain_scores_gemma":[0.9992977,0.00002129463,0.0002255573,0.0002495875,0.0001586898,0.00004720268],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005507513,0.00003180679,0.02793641,0.0001548815,0.00005777433,1.876337e-7,0.00007720877,0.0006422811,0.9651306,0.0000167063,0.000003539806,0.005893586],"study_design_scores_gemma":[0.0007011296,0.00002925548,0.05599385,0.0000485383,0.0000459474,0.000003882027,0.00006633154,0.00113657,0.9416339,0.00009273944,0.00007122335,0.0001766403],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9909785,0.0003285382,0.008147638,0.00001980323,0.00002669701,0.0004146689,0.00001904334,0.00001593399,0.00004913448],"genre_scores_gemma":[0.9992823,0.00008025446,0.0001415581,0.00001856931,0.000091528,0.00001842747,0.0002911703,0.00002598986,0.00005022546],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02805744,"threshold_uncertainty_score":0.6955696,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004556181651041628,"score_gpt":0.1926660012093687,"score_spread":0.1881098195583271,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}