{"id":"W2948699977","doi":"10.1097/fjc.0000000000000673","title":"Role of Mitochondrial Aldehyde Dehydrogenase in Nitroglycerin-Mediated Vasodilation: Observations Concerning the Dose–Response Relationship","year":2019,"lang":"en","type":"article","venue":"Journal of Cardiovascular Pharmacology","topic":"Cardiovascular Function and Risk Factors","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sinai Health System; Lunenfeld-Tanenbaum Research Institute; Toronto General Hospital; University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Aldehyde dehydrogenase; Nitroglycerin (drug); Vasodilation; Enzyme; Pharmacology; Plethysmograph; ALDH2; Medicine; Brachial artery; Chemistry; Anesthesia; Internal medicine; Biochemistry; Blood pressure","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002145757,0.0001918901,0.0009012016,0.000419632,0.00007610895,0.00001301016,0.0001862132,0.0001923181,0.0002848751],"category_scores_gemma":[0.0005871629,0.0001405933,0.001933549,0.0006856222,0.0001265529,0.0001921542,0.0000463553,0.0007602985,0.00003953246],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002088938,"about_ca_system_score_gemma":0.0005715141,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003876982,"about_ca_topic_score_gemma":0.000003721164,"domain_scores_codex":[0.9967443,0.001108952,0.000897282,0.0002066798,0.0007851219,0.0002576515],"domain_scores_gemma":[0.9975863,0.0009162134,0.0004239225,0.0004077537,0.0005114062,0.0001544115],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.01235353,0.0003824368,0.4114801,0.0001106333,0.01457943,0.0003744424,0.001647738,0.114334,0.4408021,0.0001719375,0.001158337,0.002605263],"study_design_scores_gemma":[0.02093096,0.0006062489,0.6115855,0.0001116779,0.004081421,0.001842498,0.001221351,0.001899334,0.0206631,0.00006224251,0.3367172,0.0002784849],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9871371,0.009292465,0.000361057,0.0005856304,0.001645344,0.0006745403,0.000007985203,0.00001794358,0.0002779671],"genre_scores_gemma":[0.9979798,0.0006002143,0.0003702941,0.0002108175,0.0006845965,0.00001583138,0.0000147703,0.00003026945,0.00009345865],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.420139,"threshold_uncertainty_score":0.5733228,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02600585185767356,"score_gpt":0.2714160447156572,"score_spread":0.2454101928579836,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}