{"id":"W2948719773","doi":"10.1371/journal.pone.0216533","title":"Immunogenicity and safety of a quadrivalent plant-derived virus like particle influenza vaccine candidate—Two randomized Phase II clinical trials in 18 to 49 and ≥50 years old adults","year":2019,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Influenza Virus Research Studies","field":"Medicine","cited_by":128,"is_retracted":false,"has_abstract":true,"ca_institutions":"Medicago (Canada); Caprion (Canada); McGill University Health Centre","funders":"Canadian Institutes of Health Research","keywords":"Immunogenicity; Heterologous; Medicine; Immunology; Virology; Hemagglutinin (influenza); Live attenuated influenza vaccine; Vaccination; Placebo; Influenza vaccine; Influenza A virus; Virus; Immune system; Biology; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003673097,0.001685975,0.001935793,0.000432108,0.0004551911,0.0009285436,0.0008451423,0.001816242,0.004153276],"category_scores_gemma":[0.001693958,0.0006933298,0.001321985,0.0004347554,0.001091178,0.0009162779,0.0003817902,0.002615578,0.0008325641],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007261719,"about_ca_system_score_gemma":0.001322934,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006954988,"about_ca_topic_score_gemma":0.00105489,"domain_scores_codex":[0.9990243,0.0005262452,0.00007680249,0.0001457915,0.00007866049,0.0001482685],"domain_scores_gemma":[0.9986244,0.0002913148,0.0003479948,0.0001180718,0.0001395867,0.0004786069],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9243972,0.03976869,0.002235994,0.0004521033,0.0005918787,0.00007588018,0.0001065188,0.0004303741,0.01664543,0.00007108922,0.000539016,0.01468586],"study_design_scores_gemma":[0.5397081,0.4523644,0.004273911,0.00002103138,0.0003615748,0.00006303553,0.00003081575,0.0002555606,0.002015753,0.00007545372,0.0008154231,0.00001484591],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9897553,0.001365038,0.0005833669,0.0002240382,0.0001532358,0.006353569,0.0008056593,0.00004176284,0.0007180112],"genre_scores_gemma":[0.9811689,0.00154052,0.001616846,0.0006760302,0.000270205,0.01033075,0.001686185,0.00001868276,0.002691882],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004153276,"threshold_uncertainty_score":0.01942539,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1705587932562774,"score_gpt":0.4307381459831865,"score_spread":0.2601793527269092,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}