{"id":"W2948719773","doi":"10.1371/journal.pone.0216533","title":"Immunogenicity and safety of a quadrivalent plant-derived virus like particle influenza vaccine candidate—Two randomized Phase II clinical trials in 18 to 49 and ≥50 years old adults","year":2019,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Influenza Virus Research Studies","field":"Medicine","cited_by":128,"is_retracted":false,"has_abstract":true,"ca_institutions":"Medicago (Canada); Caprion (Canada); McGill University Health Centre","funders":"Canadian Institutes of Health Research","keywords":"Immunogenicity; Heterologous; Medicine; Immunology; Virology; Hemagglutinin (influenza); Live attenuated influenza vaccine; Vaccination; Placebo; Influenza vaccine; Influenza A virus; Virus; Immune system; Biology; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.007143657,0.0002403448,0.002798576,0.0001865126,0.00006756101,0.00001749743,0.0001170477,0.0001183422,0.0002235881],"category_scores_gemma":[0.007990626,0.000190846,0.0001763347,0.0002231976,0.0001636002,0.000104095,0.0003669429,0.0003641967,0.00004699923],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006679325,"about_ca_system_score_gemma":0.0001036049,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00172574,"about_ca_topic_score_gemma":0.0003896461,"domain_scores_codex":[0.9953806,0.001194739,0.001927195,0.0004758979,0.000557143,0.0004644693],"domain_scores_gemma":[0.9961258,0.002558717,0.0003410414,0.0004703695,0.0001755189,0.0003285249],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.6387615,0.003570379,0.06388129,0.0003640238,0.001771815,0.00003000885,0.002646886,0.000003573576,0.2871609,0.00001781834,0.0001400171,0.001651799],"study_design_scores_gemma":[0.8448116,0.003830274,0.08194508,0.001607023,0.0008334055,0.000005558086,0.0002730333,0.001147781,0.06470818,0.00002426604,0.0004858254,0.0003279989],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924403,0.002449127,0.000003990444,0.000446081,0.00004636962,0.004332653,0.0002041306,0.00003258135,0.00004470901],"genre_scores_gemma":[0.9942783,0.003851602,0.0004727132,0.001032738,0.000087196,0.0001459385,0.00001465142,0.00002701351,0.000089815],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2224527,"threshold_uncertainty_score":0.9566103,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1705587932562774,"score_gpt":0.4307381459831865,"score_spread":0.2601793527269092,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}