{"id":"W2948759662","doi":"10.1093/ecco-jcc/jjz110","title":"IM-UNITI: Three-year Efficacy, Safety, and Immunogenicity of Ustekinumab Treatment of Crohn’s Disease","year":2019,"lang":"en","type":"article","venue":"Journal of Crohn s and Colitis","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":210,"is_retracted":false,"has_abstract":true,"ca_institutions":"Robarts Clinical Trials; Western University","funders":"Janssen Research and Development; Janssen Scientific Affairs","keywords":"Ustekinumab; Medicine; Adverse effect; Placebo; Crohn's disease; Internal medicine; Randomization; Randomized controlled trial; Surgery; Disease; Adalimumab; Alternative medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002982289,0.0003627455,0.0009393562,0.0002821188,0.0002227549,0.0004186212,0.0004714651,0.0004764187,0.00224886],"category_scores_gemma":[0.001668405,0.00019167,0.000554232,0.0002868721,0.0004157979,0.0005519768,0.0003989407,0.001324353,0.0003131922],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004916314,"about_ca_system_score_gemma":0.0003706856,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002648803,"about_ca_topic_score_gemma":0.000399301,"domain_scores_codex":[0.9991649,0.0004762654,0.00006863813,0.00007702516,0.0001072189,0.0001059519],"domain_scores_gemma":[0.9986932,0.0002058866,0.0005596678,0.0001519601,0.00007426761,0.000315052],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.5878668,0.02532578,0.04532944,0.00144265,0.001011314,0.0001934886,0.0005523759,0.001578695,0.0480829,0.0002751898,0.002534278,0.285807],"study_design_scores_gemma":[0.07475264,0.6320708,0.2499765,0.0001592255,0.001294755,0.0006739352,0.0001439398,0.002994042,0.03248789,0.0001766014,0.00520256,0.00006706647],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963728,0.002383042,0.000179751,0.0001253372,0.0000283853,0.0001342626,0.0001675238,0.00003257676,0.0005762973],"genre_scores_gemma":[0.9980918,0.0003643073,0.0004284667,0.00007757571,0.00005387341,0.0001659013,0.0002892241,0.000004782107,0.0005241017],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002982289,"threshold_uncertainty_score":0.01577204,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006937832353740044,"score_gpt":0.2315772906198262,"score_spread":0.2246394582660861,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}