{"id":"W2948759662","doi":"10.1093/ecco-jcc/jjz110","title":"IM-UNITI: Three-year Efficacy, Safety, and Immunogenicity of Ustekinumab Treatment of Crohn’s Disease","year":2019,"lang":"en","type":"article","venue":"Journal of Crohn s and Colitis","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":210,"is_retracted":false,"has_abstract":true,"ca_institutions":"Robarts Clinical Trials; Western University","funders":"Janssen Research and Development; Janssen Scientific Affairs","keywords":"Ustekinumab; Medicine; Adverse effect; Placebo; Crohn's disease; Internal medicine; Randomization; Randomized controlled trial; Surgery; Disease; Adalimumab; Alternative medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001161286,0.0001366635,0.000294874,0.0000507593,0.00004270158,0.00001659656,0.00009679991,0.00007286365,0.00006792956],"category_scores_gemma":[0.0000302371,0.0001145178,0.0001811981,0.00003197974,0.0001485725,0.00001010985,0.0000602684,0.00004629261,0.000001306227],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002231203,"about_ca_system_score_gemma":0.0001992018,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003152933,"about_ca_topic_score_gemma":0.00002599526,"domain_scores_codex":[0.9990724,0.00005518652,0.000429965,0.0001347283,0.0001550475,0.000152716],"domain_scores_gemma":[0.9990182,0.00002059894,0.0003421282,0.0002257849,0.0002079669,0.0001853018],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.2702169,0.003693048,0.5850185,0.001751816,0.003416209,0.003439478,0.001293524,0.0003198388,0.06665982,0.00475759,0.0007828659,0.05865043],"study_design_scores_gemma":[0.003206684,0.0006691428,0.9890614,0.00006943606,0.0001310906,0.00005306732,0.00008430602,0.00001558139,0.004249556,0.0001308194,0.002215106,0.0001138536],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968497,0.002303372,0.00002694889,0.00004091333,0.00008608265,0.0002027622,0.000150063,0.000001438588,0.0003387651],"genre_scores_gemma":[0.997919,0.001673378,0.00007375952,0.00002314002,0.00009886056,0.000001745739,0.0000104668,0.00001356308,0.000186091],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4040429,"threshold_uncertainty_score":0.46699,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006937832353740044,"score_gpt":0.2315772906198262,"score_spread":0.2246394582660861,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}