{"id":"W2948786278","doi":"10.1161/res.121.suppl_1.409","title":"Abstract 409: LRRC10 Associates With and Regulates Cardiac Ca V 1.2 L-type Ca 2+ Channels, and I195T LRRC10 Variant is Linked to Dilated Cardiomyopathy","year":2017,"lang":"en","type":"article","venue":"Circulation Research","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Stuart Olson (Canada)","funders":"","keywords":"Colocalization; Myocyte; Dilated cardiomyopathy; Cav1.2; Immunoprecipitation; Cardiomyopathy; Patch clamp; Molecular biology; HEK 293 cells; Biology; Immunocytochemistry; Internal medicine; Ion channel; Wild type; Endocrinology; Missense mutation; Nav1.5; Cell biology; Electrophysiology; Chemistry; Voltage-dependent calcium channel; Medicine; Mutation; Heart failure; Biochemistry; Calcium; Gene; Sodium channel; Receptor; Mutant","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001224598,0.000443786,0.0002589436,0.0002102629,0.0001670266,0.0003251015,0.0003756889,0.0004959853,0.004171785],"category_scores_gemma":[0.0001409918,0.0001508883,0.0003333544,0.0001336033,0.0004094568,0.0002112658,0.0002203255,0.000639033,0.001971837],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004153294,"about_ca_system_score_gemma":0.0001350317,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006358293,"about_ca_topic_score_gemma":0.0007811052,"domain_scores_codex":[0.9997854,0.0000243329,0.00001988626,0.00007131282,0.00006216457,0.00003691009],"domain_scores_gemma":[0.9998271,0.00001806006,0.00006943719,0.00001523544,0.00001631892,0.00005388376],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001003025,0.00001438673,0.0002878006,0.00002020779,0.000004434239,0.0001696923,0.000008370958,0.00001425198,0.998929,0.00003543376,0.000114614,0.0003015319],"study_design_scores_gemma":[0.0000739458,0.0003022191,0.0549093,0.00002718014,0.00003411313,0.003786807,0.000113567,0.001626806,0.9338102,0.0001608991,0.005140922,0.0000140156],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9909945,0.001439215,0.003404228,0.0004605109,0.00009939227,0.0000202226,0.001335992,0.0001859375,0.00206001],"genre_scores_gemma":[0.9890994,0.0004499667,0.00152408,0.0002922234,0.00005492978,0.00004344649,0.001617857,0.00009774854,0.00682035],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004171785,"threshold_uncertainty_score":0.01395601,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03254484708222873,"score_gpt":0.2986334395682596,"score_spread":0.2660885924860308,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}