{"id":"W2948786278","doi":"10.1161/res.121.suppl_1.409","title":"Abstract 409: LRRC10 Associates With and Regulates Cardiac Ca <sub>V</sub> 1.2 L-type Ca <sup>2+</sup> Channels, and I195T LRRC10 Variant is Linked to Dilated Cardiomyopathy","year":2017,"lang":"en","type":"article","venue":"Circulation Research","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Stuart Olson (Canada)","funders":"","keywords":"Colocalization; Myocyte; Dilated cardiomyopathy; Cav1.2; Immunoprecipitation; Cardiomyopathy; Patch clamp; Molecular biology; HEK 293 cells; Biology; Immunocytochemistry; Internal medicine; Ion channel; Wild type; Endocrinology; Missense mutation; Nav1.5; Cell biology; Electrophysiology; Chemistry; Voltage-dependent calcium channel; Medicine; Mutation; Heart failure; Biochemistry; Calcium; Gene; Sodium channel; Receptor; Mutant","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001181706,0.0002610057,0.0003106185,0.0002245265,0.0009945603,0.0003860005,0.0001916282,0.000405382,0.0000296621],"category_scores_gemma":[0.0004830062,0.0002448559,0.00008044948,0.0002349558,0.0002339115,0.00004715048,0.0002181695,0.0002861549,0.00004308004],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006611353,"about_ca_system_score_gemma":0.0001499285,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002807135,"about_ca_topic_score_gemma":0.00002136359,"domain_scores_codex":[0.9976944,0.0001774062,0.000281668,0.0007560977,0.0005653078,0.0005250811],"domain_scores_gemma":[0.9978798,0.00005634561,0.0001318782,0.0006880421,0.0009276969,0.0003162496],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.002139152,0.0002470103,0.09567443,0.0003707782,0.001256066,0.00008467067,0.004130668,0.05016557,0.8016179,0.0002979232,0.0251288,0.01888703],"study_design_scores_gemma":[0.002287127,0.0007470748,0.8612935,0.0001771928,0.0000972768,0.0000641139,0.0009517596,0.05888299,0.06043061,0.0004919296,0.01358494,0.0009914654],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966205,0.0004563087,0.0001665684,0.001164839,0.0002700885,0.0006597538,0.0000814617,0.00002964867,0.0005507971],"genre_scores_gemma":[0.9980474,0.0003044458,0.00004235113,0.0001010056,0.0007053209,0.0000467356,0.0003324233,0.00005212994,0.000368198],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7656191,"threshold_uncertainty_score":0.9984933,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03254484708222873,"score_gpt":0.2986334395682596,"score_spread":0.2660885924860308,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}