{"id":"W2948862058","doi":"10.1242/jcs.228411","title":"Yeast ceramide synthases, Lag1 and Lac1, have distinct substrate specificity","year":2019,"lang":"en","type":"article","venue":"Journal of Cell Science","topic":"Lipid Membrane Structure and Behavior","field":"Biochemistry, Genetics and Molecular Biology","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; Institute of Genetics and Genomics of Geneva; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Seventh Framework Programme; National Center of Competence in Research Chemical Biology; Weizmann Institute of Science; Volkswagen Foundation","keywords":"Biology; Ceramide; Saccharomyces cerevisiae; Enzyme; Yeast; Sphingolipid; Function (biology); Biochemistry; Cell biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003482901,0.00008554361,0.0001220789,0.00004247541,0.00006035301,0.00005947072,0.0002383824,0.00004470008,0.00005004807],"category_scores_gemma":[0.00003113553,0.00006191972,0.00005066809,0.00007606965,0.0002111413,0.00001602101,0.00005967532,0.0001049128,0.000005708939],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001237906,"about_ca_system_score_gemma":0.0001484471,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005412357,"about_ca_topic_score_gemma":0.0000108085,"domain_scores_codex":[0.9992105,0.00001722445,0.0001793204,0.0001784543,0.0002372821,0.0001771874],"domain_scores_gemma":[0.9994234,0.000006437492,0.0001616579,0.0001560899,0.0001225277,0.0001298494],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002472378,0.00002210228,0.01421437,0.000007543683,0.000002191006,0.000008116637,0.00002133647,0.000004803217,0.9849181,0.00001009191,0.00007958616,0.0006869987],"study_design_scores_gemma":[0.0002759049,0.0002029772,0.04455918,0.000009362495,0.0000126322,0.0001584238,0.00008023214,0.00001390313,0.9490381,0.000006894975,0.005552026,0.00009038515],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959651,0.00009767078,0.00003370512,0.00003656389,0.0003826574,0.00005230228,0.000006172786,0.000001430576,0.003424449],"genre_scores_gemma":[0.9985514,0.00004432603,0.000278179,0.00004196395,0.0003219465,1.33424e-7,0.000001427921,0.000005061335,0.0007555542],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03588006,"threshold_uncertainty_score":0.2525013,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007562462602325486,"score_gpt":0.2354100510487568,"score_spread":0.2278475884464313,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}