{"id":"W2948862058","doi":"10.1242/jcs.228411","title":"Yeast ceramide synthases, Lag1 and Lac1, have distinct substrate specificity","year":2019,"lang":"en","type":"article","venue":"Journal of Cell Science","topic":"Lipid Membrane Structure and Behavior","field":"Biochemistry, Genetics and Molecular Biology","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; Institute of Genetics and Genomics of Geneva; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Seventh Framework Programme; National Center of Competence in Research Chemical Biology; Weizmann Institute of Science; Volkswagen Foundation","keywords":"Biology; Ceramide; Saccharomyces cerevisiae; Enzyme; Yeast; Sphingolipid; Function (biology); Biochemistry; Cell biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001647313,0.0005958729,0.0002897904,0.0003895888,0.0001414801,0.0007478006,0.000281929,0.0003317464,0.0007697128],"category_scores_gemma":[0.0002577495,0.0002416453,0.0002350338,0.0002717525,0.0003236317,0.0003438237,0.0005265222,0.0005230735,0.0008881459],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005697946,"about_ca_system_score_gemma":0.0002820021,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006374035,"about_ca_topic_score_gemma":0.0007994701,"domain_scores_codex":[0.9998502,0.00001529114,0.00001749196,0.00003883854,0.00004949073,0.00002875608],"domain_scores_gemma":[0.9997374,0.00003411935,0.00007216277,0.00002715178,0.00004316398,0.00008597135],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001127351,0.00001129505,0.0006511553,0.00003722611,0.000004228201,0.00005538033,0.00002607764,0.00007356206,0.9954762,0.0003113559,0.00003512776,0.003205584],"study_design_scores_gemma":[0.00001612647,0.00008582894,0.006340427,0.000007551855,0.0000115272,0.0005854577,0.00005328,0.0006553124,0.988134,0.000281669,0.003814583,0.00001424087],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9812546,0.005923455,0.009501357,0.0002545059,0.00004084715,0.00002496417,0.0009201103,0.0002943919,0.00178574],"genre_scores_gemma":[0.9890276,0.001483288,0.004999966,0.00007879005,0.000009524087,0.00002732364,0.001883231,0.00005431137,0.002435956],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007697128,"threshold_uncertainty_score":0.004134119,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007562462602325486,"score_gpt":0.2354100510487568,"score_spread":0.2278475884464313,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}