{"id":"W2948862715","doi":"10.1038/s41398-019-0494-6","title":"Validation of the animal model of bipolar disorder induced by Ouabain: face, construct and predictive perspectives","year":2019,"lang":"en","type":"article","venue":"Translational Psychiatry","topic":"Bipolar Disorder and Treatment","field":"Medicine","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Instituto Mente e Cérebro - Neurociência; Universidade do Extremo Sul Catarinense; Fundação de Amparo à Pesquisa e Inovação do Estado de Santa Catarina; University of Toronto; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; McGovern Medical School; Conselho Nacional de Desenvolvimento Científico e Tecnológico; University of Texas Health Science Center at Houston","keywords":"Neurochemical; Bipolar disorder; Psychology; Ouabain; Mood; Lithium (medication); Glucocorticoid; Animal model; Animal studies; Internal medicine; Endocrinology; Pharmacology; Chemistry; Neuroscience; Psychiatry; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001020366,0.0008514816,0.0006303909,0.001137063,0.0005767003,0.0006060243,0.0004490861,0.0005533137,0.001924181],"category_scores_gemma":[0.0003977148,0.000236842,0.0004988504,0.0004008107,0.0006721132,0.0005277107,0.0003991406,0.001559416,0.0004667277],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004941313,"about_ca_system_score_gemma":0.0005605067,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002255021,"about_ca_topic_score_gemma":0.004002357,"domain_scores_codex":[0.9995267,0.0001090679,0.00005074971,0.00008069425,0.0001478558,0.00008488796],"domain_scores_gemma":[0.9995394,0.0000527269,0.0001088966,0.00008810309,0.000116974,0.00009388637],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00135098,0.001428808,0.002524964,0.000306183,0.0000575936,0.0002346232,0.0001330791,0.0003762759,0.9850028,0.0007781307,0.0004248652,0.00738177],"study_design_scores_gemma":[0.0004357072,0.02737665,0.03224451,0.0002357164,0.0004966559,0.001333293,0.0005817548,0.005041253,0.909741,0.00129812,0.0210868,0.0001284469],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9397072,0.004820096,0.04157417,0.001091115,0.0004697809,0.001874902,0.004259389,0.0005548008,0.005648635],"genre_scores_gemma":[0.9397327,0.007054796,0.03745075,0.0005286518,0.0001313636,0.003133289,0.004348303,0.0001227248,0.007497369],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002255021,"threshold_uncertainty_score":0.006437063,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01080037017692805,"score_gpt":0.2507181696873552,"score_spread":0.2399177995104272,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}