{"id":"W2948894715","doi":"10.1007/s40266-019-00681-w","title":"Population Pharmacokinetic/Pharmacodynamic Modeling of O-Desmethyltramadol in Young and Elderly Healthy Volunteers","year":2019,"lang":"en","type":"article","venue":"Drugs & Aging","topic":"Veterinary Pharmacology and Anesthesia","field":"Veterinary","cited_by":6,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université du Québec; Université de Montréal","funders":"","keywords":"Medicine; Pharmacokinetics; Pharmacodynamics; Placebo; Volume of distribution; Population; NONMEM; Tramadol; Anesthesia; Internal medicine; Analgesic","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005031074,0.0002043459,0.0003313557,0.0002719595,0.00006536478,0.00001521194,0.0001503695,0.00008283489,0.0001396776],"category_scores_gemma":[0.000004641375,0.0002262607,0.00006158001,0.0001887993,0.00003526807,0.0003051073,0.00006116599,0.0003383427,0.00002775439],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006281614,"about_ca_system_score_gemma":0.0000227368,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001270887,"about_ca_topic_score_gemma":0.00001467412,"domain_scores_codex":[0.9984528,0.0002027533,0.0004385882,0.0003731721,0.000160928,0.0003716865],"domain_scores_gemma":[0.999563,0.00007150305,0.000110073,0.0001513232,0.00002766534,0.00007641352],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.002485038,0.0002904531,0.4590416,0.001105514,0.0001184723,0.0002417418,0.01301399,0.04393334,0.4546082,0.0002404192,0.00002887594,0.02489237],"study_design_scores_gemma":[0.002421391,0.0004465235,0.05641359,0.000154927,0.00004968761,0.0002913945,0.0005253321,0.9389757,0.0001762005,0.0001681277,0.00005428034,0.0003228454],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975612,0.0003983637,0.0001752163,0.0002445432,0.0003021568,0.0003772861,0.000004465627,0.00007161196,0.0008651619],"genre_scores_gemma":[0.9989671,0.00009811474,0.0004984298,0.0002351877,0.00005475936,0.000017303,0.00001909848,0.00003623413,0.00007375311],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8950424,"threshold_uncertainty_score":0.9226646,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02340503072661255,"score_gpt":0.3330472555610952,"score_spread":0.3096422248344827,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}