{"id":"W2948900598","doi":"10.1016/s1470-2045(19)30150-0","title":"Quizartinib versus salvage chemotherapy in relapsed or refractory FLT3-ITD acute myeloid leukaemia (QuANTUM-R): a multicentre, randomised, controlled, open-label, phase 3 trial","year":2019,"lang":"en","type":"article","venue":"The Lancet Oncology","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":479,"is_retracted":false,"has_abstract":false,"ca_institutions":"Vancouver General Hospital","funders":"Daiichi-Sankyo; Incyte; National Cancer Institute; National Cancer Research Institute; Celgene","keywords":"Medicine; Cytarabine; Internal medicine; Chemotherapy; Salvage therapy; Chemotherapy regimen; Febrile neutropenia; Etoposide; Surgery; Mitoxantrone; Fludarabine; Phases of clinical research; Transplantation; Refractory (planetary science); Oncology; Gastroenterology; Neutropenia; Cyclophosphamide","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.004834981,0.0005160489,0.00322813,0.0002583583,0.0001560493,0.00008163437,0.001432463,0.000593186,0.002486354],"category_scores_gemma":[0.002403027,0.0003097717,0.0002146037,0.0006310203,0.0003593787,0.0002042657,0.0003945669,0.001940195,0.00102693],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001865642,"about_ca_system_score_gemma":0.002694064,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000237129,"about_ca_topic_score_gemma":0.0002518478,"domain_scores_codex":[0.9940971,0.001822007,0.001224247,0.0008429292,0.00061852,0.001395206],"domain_scores_gemma":[0.9915956,0.005741438,0.0005953174,0.001549245,0.0001963505,0.000322069],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9343994,0.002596127,0.00009135695,0.00005597408,0.0009621986,0.0008062828,0.001076899,0.000006421541,0.02712792,0.0002044086,0.02157367,0.01109932],"study_design_scores_gemma":[0.8707371,0.01471438,0.00009417959,0.0000802201,0.0003546975,0.00008397985,0.0004286719,0.005053406,0.0007152452,0.00004238156,0.1073774,0.0003183662],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9533827,0.0004359538,0.00002044603,0.01440867,0.001678913,0.01445404,0.00003886881,0.0001392828,0.0154411],"genre_scores_gemma":[0.9594557,0.003880829,0.002068767,0.01143362,0.003269628,0.002373901,0.0001666627,0.0002398731,0.01711098],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08580371,"threshold_uncertainty_score":0.9999354,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09386240084003972,"score_gpt":0.4315224040450322,"score_spread":0.3376600032049925,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}