{"id":"W2948900598","doi":"10.1016/s1470-2045(19)30150-0","title":"Quizartinib versus salvage chemotherapy in relapsed or refractory FLT3-ITD acute myeloid leukaemia (QuANTUM-R): a multicentre, randomised, controlled, open-label, phase 3 trial","year":2019,"lang":"en","type":"article","venue":"The Lancet Oncology","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":479,"is_retracted":false,"has_abstract":false,"ca_institutions":"Vancouver General Hospital","funders":"Daiichi-Sankyo; Incyte; National Cancer Institute; National Cancer Research Institute; Celgene","keywords":"Medicine; Cytarabine; Internal medicine; Chemotherapy; Salvage therapy; Chemotherapy regimen; Febrile neutropenia; Etoposide; Surgery; Mitoxantrone; Fludarabine; Phases of clinical research; Transplantation; Refractory (planetary science); Oncology; Gastroenterology; Neutropenia; Cyclophosphamide","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001059008,0.001207066,0.002727192,0.0002535818,0.0003270604,0.0009048001,0.0007667676,0.001231481,0.005781992],"category_scores_gemma":[0.00115981,0.000377981,0.001731516,0.0003141467,0.0008797466,0.0009274637,0.0003631849,0.002605891,0.0008699097],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008354135,"about_ca_system_score_gemma":0.0007548274,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001276492,"about_ca_topic_score_gemma":0.003751199,"domain_scores_codex":[0.9996334,0.0001813426,0.00001666564,0.00007199333,0.00002415853,0.00007238954],"domain_scores_gemma":[0.999594,0.0001133641,0.00009459435,0.00003113583,0.00002436971,0.0001424125],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9562276,0.002977913,0.0005035018,0.001209327,0.001426528,0.00005490393,0.00006516155,0.0007814037,0.003050586,0.0003317558,0.002510894,0.03086033],"study_design_scores_gemma":[0.9600927,0.03559123,0.001746925,0.00004726216,0.0005341834,0.00004752073,0.0000243938,0.0005445497,0.0002288586,0.00030343,0.000821238,0.00001772605],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.985232,0.006620792,0.000733291,0.001055243,0.0007052656,0.002025118,0.001131448,0.0001893859,0.002307499],"genre_scores_gemma":[0.9871861,0.003321127,0.001247173,0.00136296,0.0002478958,0.00188403,0.00105481,0.00002653536,0.003669389],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005781992,"threshold_uncertainty_score":0.01934266,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09386240084003972,"score_gpt":0.4315224040450322,"score_spread":0.3376600032049925,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}