{"id":"W2948923376","doi":"10.1056/nejmoa1904819","title":"Clinical and Genomic Risk to Guide the Use of Adjuvant Therapy for Breast Cancer","year":2019,"lang":"en","type":"article","venue":"New England Journal of Medicine","topic":"Breast Cancer Treatment Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":555,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Sunnybrook Hospital","funders":"National Cancer Institute","keywords":"Breast cancer; Medicine; Oncology; Internal medicine; Adjuvant; Adjuvant therapy; Adjuvant chemotherapy; Chemotherapy; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000431546,0.00008438084,0.0002670985,0.00002250424,0.00002454127,0.000003115186,0.00008868948,0.00003584677,0.00002336625],"category_scores_gemma":[0.0001084163,0.00004086136,0.00006137085,0.00002637384,0.00008152606,0.000002700383,0.0000276229,0.00006852322,3.240696e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008164844,"about_ca_system_score_gemma":0.0000911868,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003478339,"about_ca_topic_score_gemma":0.0001298307,"domain_scores_codex":[0.9993289,0.00005653414,0.0003255455,0.0001041151,0.00009444842,0.0000904655],"domain_scores_gemma":[0.9992582,0.0001402638,0.0002324879,0.0001355979,0.0001500795,0.00008333041],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002735998,0.00002829397,0.4960603,0.000006899076,0.0004093925,0.000001183035,0.0002787507,0.00008368366,0.01371909,0.000005348903,0.01877842,0.4678927],"study_design_scores_gemma":[0.02282835,0.001417298,0.6933634,0.00007757104,0.0001230528,0.0001169411,0.00007384289,0.000007658765,0.0007011218,0.00003500774,0.2812002,0.00005563337],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9848425,0.006283385,0.0003502101,0.007880885,0.0003980335,0.0001755269,0.0000538782,7.703648e-7,0.00001482875],"genre_scores_gemma":[0.9752508,0.01981935,0.0007005077,0.001093379,0.002916928,0.000003130184,0.000002329777,0.00001076769,0.0002028163],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.467837,"threshold_uncertainty_score":0.1666278,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03262880315139176,"score_gpt":0.3362689219197941,"score_spread":0.3036401187684023,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}