{"id":"W2948923376","doi":"10.1056/nejmoa1904819","title":"Clinical and Genomic Risk to Guide the Use of Adjuvant Therapy for Breast Cancer","year":2019,"lang":"en","type":"article","venue":"New England Journal of Medicine","topic":"Breast Cancer Treatment Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":555,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Sunnybrook Hospital","funders":"National Cancer Institute","keywords":"Breast cancer; Medicine; Oncology; Internal medicine; Adjuvant; Adjuvant therapy; Adjuvant chemotherapy; Chemotherapy; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005128235,0.0003629024,0.0007496172,0.0006421241,0.0001505193,0.0005608281,0.0004444786,0.0007288991,0.001721108],"category_scores_gemma":[0.01954141,0.0001479078,0.0004914374,0.0005466614,0.000374119,0.0004316648,0.0003063619,0.001048873,0.0004381563],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004096485,"about_ca_system_score_gemma":0.0007341148,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005476949,"about_ca_topic_score_gemma":0.001135347,"domain_scores_codex":[0.9973266,0.001945808,0.000187649,0.0001526863,0.0003345868,0.00005267594],"domain_scores_gemma":[0.9892262,0.007233223,0.002194779,0.0002767717,0.0005928709,0.0004761417],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01400279,0.0007920605,0.7829541,0.0006134751,0.001177834,0.0001073708,0.0001329873,0.007920057,0.001464967,0.0008466041,0.008091369,0.1818964],"study_design_scores_gemma":[0.005249765,0.01096726,0.8992741,0.001012339,0.002450574,0.001128722,0.0002750579,0.03581033,0.002598616,0.0112912,0.02980306,0.0001390175],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8975406,0.04512956,0.01875796,0.02056761,0.0007963856,0.000779471,0.001626778,0.0001589387,0.01464275],"genre_scores_gemma":[0.9853931,0.002745825,0.008374598,0.001822675,0.0003191224,0.0001778696,0.0005636163,0.00001673615,0.0005864445],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005128235,"threshold_uncertainty_score":0.02712101,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03262880315139176,"score_gpt":0.3362689219197941,"score_spread":0.3036401187684023,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}