{"id":"W2948996326","doi":"10.1002/cmdc.201900334","title":"Synthesis and Study of Multifunctional Cyclodextrin–Deferasirox Hybrids","year":2019,"lang":"en","type":"article","venue":"ChemMedChem","topic":"Hemoglobinopathies and Related Disorders","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Discovery Centre","funders":"Engineering and Physical Sciences Research Council; Niemann-Pick Research Foundation; Wellcome Trust","keywords":"Deferasirox; Chemistry; Cyclodextrin; Chelation; Combinatorial chemistry; Beta-Cyclodextrins; Amide; Benzoic acid; Conjugated system; Biochemistry; Organic chemistry; Medicine; Thalassemia; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001135197,0.000129368,0.0003148477,0.00007116343,0.00003120437,0.000005181934,0.00004763001,0.0000961453,0.0004794391],"category_scores_gemma":[0.0001020206,0.0001031448,0.0000603816,0.0001322418,0.00005988876,0.00003557322,0.00004572329,0.0001661423,0.0000650756],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002526472,"about_ca_system_score_gemma":0.00003724324,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003857142,"about_ca_topic_score_gemma":0.000001504508,"domain_scores_codex":[0.9991208,0.00001408116,0.0002280684,0.0002485461,0.0002244625,0.0001640158],"domain_scores_gemma":[0.9994159,0.0001026575,0.0000602836,0.0002506439,0.00006496408,0.000105502],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007143063,0.003471225,0.8106794,0.0006286851,0.0006259221,0.00004083364,0.002057127,0.00002145535,0.1537798,0.0001468461,0.001930474,0.0259039],"study_design_scores_gemma":[0.008486075,0.0009680252,0.3836387,0.0002337425,0.0004491917,0.0001586629,0.009012935,0.0006914755,0.5923732,0.00007606264,0.003536885,0.0003750934],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9873537,0.0003427275,0.000005919545,0.0002166782,0.0001127979,0.0004240434,0.000002983805,0.00003754154,0.01150357],"genre_scores_gemma":[0.9980415,0.00005418494,0.00009722343,0.00008410164,0.00003551855,0.00001867737,0.000004883123,0.00001933409,0.001644555],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4385934,"threshold_uncertainty_score":0.5249522,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01159081832020729,"score_gpt":0.2360437888819483,"score_spread":0.224452970561741,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}