{"id":"W2948996326","doi":"10.1002/cmdc.201900334","title":"Synthesis and Study of Multifunctional Cyclodextrin–Deferasirox Hybrids","year":2019,"lang":"en","type":"article","venue":"ChemMedChem","topic":"Hemoglobinopathies and Related Disorders","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Discovery Centre","funders":"Engineering and Physical Sciences Research Council; Niemann-Pick Research Foundation; Wellcome Trust","keywords":"Deferasirox; Chemistry; Cyclodextrin; Chelation; Combinatorial chemistry; Beta-Cyclodextrins; Amide; Benzoic acid; Conjugated system; Biochemistry; Organic chemistry; Medicine; Thalassemia; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000881525,0.0002510228,0.0001387284,0.0001593364,0.000106173,0.0002345838,0.000167705,0.0002860389,0.0009154171],"category_scores_gemma":[0.00009221189,0.0001003822,0.0001779308,0.0001552979,0.0001032023,0.0001999656,0.000166456,0.0002695282,0.0003000809],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002379141,"about_ca_system_score_gemma":0.00007930765,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002385037,"about_ca_topic_score_gemma":0.0002593323,"domain_scores_codex":[0.9999454,0.00000580962,0.00000422706,0.00001780577,0.00001220646,0.00001467897],"domain_scores_gemma":[0.9999495,0.000007970903,0.00001439509,0.000004602227,0.000008369486,0.00001519456],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005855523,0.00004291925,0.00007894073,0.00007191888,0.00001383255,0.0001141603,0.0000401035,0.0005396089,0.9961665,0.0004698265,0.00006613797,0.002337655],"study_design_scores_gemma":[0.00001707372,0.0003009483,0.0005957226,0.000005098309,0.00001501157,0.0001224887,0.0000216443,0.001115519,0.9928181,0.00006856178,0.004906895,0.00001300333],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9880902,0.001466092,0.006427071,0.00008427516,0.00004195711,0.00005856585,0.0002075583,0.00006612663,0.003558148],"genre_scores_gemma":[0.9933103,0.0004695796,0.003599571,0.00005542091,0.00000792803,0.00005090935,0.0001712194,0.0000109584,0.002324087],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009154171,"threshold_uncertainty_score":0.003062367,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01159081832020729,"score_gpt":0.2360437888819483,"score_spread":0.224452970561741,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}