{"id":"W2949033967","doi":"10.1038/s41467-019-10577-3","title":"Inhibition of CRISPR-Cas9 ribonucleoprotein complex assembly by anti-CRISPR AcrIIC2","year":2019,"lang":"en","type":"article","venue":"Nature Communications","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":77,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of General Medical Sciences; Chinese Academy of Sciences; National Natural Science Foundation of China-Yunnan Joint Fund; Canadian Light Source; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; National Natural Science Foundation of China; National Institutes of Health; Government of Canada; Salt Science Research Foundation; Ministry of Science and Technology of the People's Republic of China; Foundation for the National Institutes of Health","keywords":"CRISPR; Ribonucleoprotein; Genome editing; Cas9; Trans-activating crRNA; Computational biology; Biology; Genetics; RNA; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001441717,0.0001378456,0.0001645937,0.00005006621,0.00007836837,0.00001807354,0.0005085045,0.0003074463,0.00002787461],"category_scores_gemma":[0.00007126201,0.0001462158,0.00009105467,0.0001524868,0.00006811771,0.000006339195,0.0003184482,0.0003549604,0.00002226722],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001183656,"about_ca_system_score_gemma":0.00002866698,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002484277,"about_ca_topic_score_gemma":0.00006082499,"domain_scores_codex":[0.9991893,0.00006188447,0.0002352707,0.0002139643,0.0001293052,0.0001703308],"domain_scores_gemma":[0.9981576,0.00002662312,0.00009223745,0.001499986,0.0001714272,0.00005208104],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000007402919,0.00008563762,0.001503499,0.00002320073,0.00003035393,1.219703e-7,0.00003760891,0.00004913679,0.9820703,0.0004108224,0.01525831,0.0005235774],"study_design_scores_gemma":[0.0004481792,0.0001048827,0.01002859,0.00002889658,0.00002169969,0.000006198027,0.0001012019,0.0006150536,0.7926692,0.00003136084,0.1957273,0.0002173985],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.975921,0.01005188,0.005945432,0.001381107,0.0001677436,0.0005129995,0.000178882,0.0000414633,0.00579951],"genre_scores_gemma":[0.9935135,0.0006522213,0.004429772,0.0002476737,0.00003977494,0.00001896525,0.0008633188,0.00002582515,0.0002089089],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1894011,"threshold_uncertainty_score":0.5962507,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01090340787095691,"score_gpt":0.3220277338456019,"score_spread":0.311124325974645,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}