{"id":"W2949037060","doi":"10.1101/662718","title":"New mechanism-based inhibitors of aspartate transcarbamoylase for anticancer drug development","year":2019,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Xiamen University; Natural Sciences and Engineering Research Council of Canada; National Natural Science Foundation of China","keywords":"Aspartate carbamoyltransferase; Pyrimidine metabolism; Allosteric regulation; Biochemistry; Enzyme; Biology; Chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004543877,0.0004954225,0.0005190006,0.0001389057,0.00006685394,0.00005083914,0.0005882712,0.0005914902,0.0000217815],"category_scores_gemma":[0.0001067192,0.0005136907,0.0003316697,0.0001763883,0.00008868289,0.00000443719,0.0003136877,0.0003435389,0.00001148134],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000705805,"about_ca_system_score_gemma":0.002400056,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003952433,"about_ca_topic_score_gemma":0.00000513515,"domain_scores_codex":[0.9973332,0.00007293846,0.0005467171,0.001042036,0.0004163284,0.0005887716],"domain_scores_gemma":[0.9979252,0.00002471847,0.0002758024,0.0009737202,0.0004668859,0.0003336771],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002098332,0.0001136677,0.0003071596,0.0008039016,0.0002046101,0.000003453392,0.000004496112,0.00009386202,0.9967634,0.0001023465,0.001382039,0.00001122874],"study_design_scores_gemma":[0.001156951,0.0001151839,0.0005122075,0.000266111,0.0000740086,5.100566e-9,0.000001174187,0.0001774537,0.9840381,0.000003767548,0.0130646,0.000590448],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9382146,0.001529828,0.05756876,0.0002373531,0.0006268612,0.001506505,0.0002588958,0.00005067248,0.00000655577],"genre_scores_gemma":[0.9792152,0.0001016469,0.01975734,0.0001901138,0.0003092518,0.0002378302,0.000008062138,0.0001317595,0.0000488163],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04100061,"threshold_uncertainty_score":0.9997315,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01148841476960453,"score_gpt":0.2351979304582234,"score_spread":0.2237095156886189,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}