{"id":"W2949037060","doi":"10.1101/662718","title":"New mechanism-based inhibitors of aspartate transcarbamoylase for anticancer drug development","year":2019,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Xiamen University; Natural Sciences and Engineering Research Council of Canada; National Natural Science Foundation of China","keywords":"Aspartate carbamoyltransferase; Pyrimidine metabolism; Allosteric regulation; Biochemistry; Enzyme; Biology; Chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000327431,0.0005769476,0.0005530302,0.0003739642,0.000160854,0.0006382801,0.0005881554,0.0004302851,0.001785684],"category_scores_gemma":[0.0001180817,0.000229478,0.0004065574,0.0002174666,0.0002493861,0.0004102607,0.0003611096,0.0008280909,0.0006157881],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005284174,"about_ca_system_score_gemma":0.0002960934,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000274897,"about_ca_topic_score_gemma":0.0005962904,"domain_scores_codex":[0.9998878,0.00001890013,0.000007248697,0.00002773732,0.0000368482,0.00002145859],"domain_scores_gemma":[0.9999585,0.000006150734,0.00001058622,0.000005471688,0.000008157799,0.00001116102],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003854777,0.0004142875,0.0004542152,0.0004038097,0.00008143673,0.0002503063,0.00003779345,0.003844723,0.9416462,0.006614336,0.00156059,0.04430694],"study_design_scores_gemma":[0.0008490902,0.002720945,0.001047733,0.00004704339,0.0001557418,0.0009885236,0.00002165661,0.0157844,0.9298272,0.001821615,0.0466867,0.0000494267],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7845631,0.05987895,0.1161114,0.002265745,0.0008418798,0.001067442,0.001784695,0.002078895,0.03140794],"genre_scores_gemma":[0.9469277,0.01252691,0.03056707,0.000418858,0.00006612662,0.0002222396,0.000885305,0.00005765994,0.008328085],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001785684,"threshold_uncertainty_score":0.005973756,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01148841476960453,"score_gpt":0.2351979304582234,"score_spread":0.2237095156886189,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}