{"id":"W2949073425","doi":"10.3987/com-13-s(s)18","title":"Expedient Synthesis of 2-Oxopiperazines Using a SN2 / Cope-Type Hydroamination Sequence","year":2013,"lang":"en","type":"article","venue":"Heterocycles","topic":"Chemical synthesis and alkaloids","field":"Chemistry","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"","keywords":"Hydroamination; Chemistry; Intramolecular force; SN2 reaction; Sequence (biology); Yield (engineering); Combinatorial chemistry; Allylic rearrangement; Molecule; Natural product; Chemical synthesis; Stereochemistry; Organic chemistry; Catalysis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.00004100486,0.0001534959,0.0002335959,0.0000353249,0.00005694942,0.00003431968,0.0001775229,0.00009639056,0.00161522],"category_scores_gemma":[0.0001695893,0.0001333181,0.00008658443,0.00007561154,0.00008848839,0.0001588207,0.00006607566,0.00006783817,0.00005753701],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006376184,"about_ca_system_score_gemma":0.00001197529,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002690016,"about_ca_topic_score_gemma":0.000004397377,"domain_scores_codex":[0.9990314,0.00001376755,0.0002972993,0.0002364756,0.0002055116,0.0002155285],"domain_scores_gemma":[0.9992961,0.0001628521,0.0001247594,0.0002524453,0.00008861381,0.00007520936],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000006934639,0.00006170799,0.001558909,0.0001183212,0.00001956275,0.000001174124,0.00007687249,0.00001463355,0.9828505,0.00001552666,0.0001066985,0.01516917],"study_design_scores_gemma":[0.00008335787,0.000006291298,0.0003278821,0.0001951548,0.00002306821,0.000007277121,0.0001225698,0.002855049,0.9956064,0.000149594,0.0004622048,0.0001612024],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963751,0.0001988051,0.00002135801,0.0000537618,0.00004606165,0.00005400243,0.000008694597,0.00005040051,0.003191747],"genre_scores_gemma":[0.9987361,0.00005342023,0.0008615993,0.00002239532,0.0001081396,0.00002722381,0.000005659313,0.00002091612,0.0001645006],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01500797,"threshold_uncertainty_score":0.9992974,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03580597269709056,"score_gpt":0.2679052071465334,"score_spread":0.2320992344494428,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}