{"id":"W2949089116","doi":"10.1002/chin.201012202","title":"ChemInform Abstract: Scaffold‐Based Design and Synthesis of Potent N‐Type Calcium Channel Blockers.","year":2010,"lang":"en","type":"article","venue":"ChemInform","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; Michael Smith Health Research BC","funders":"","keywords":"Chemistry; Scaffold; Calcium channel; Channel (broadcasting); Combinatorial chemistry; Type (biology); Nanotechnology; Calcium; Database; Computer network; Organic chemistry; Computer science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003242173,0.00112676,0.0006457511,0.000592224,0.0002946988,0.0006098249,0.0008241703,0.0004333069,0.009018003],"category_scores_gemma":[0.0002464619,0.0003475522,0.00039288,0.0004174377,0.0002430073,0.0005996593,0.0005008161,0.0007970387,0.004379456],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004707878,"about_ca_system_score_gemma":0.0009697857,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006206544,"about_ca_topic_score_gemma":0.001565896,"domain_scores_codex":[0.9998673,0.00001846054,0.00001075889,0.00002725332,0.00004143158,0.00003477077],"domain_scores_gemma":[0.9999342,0.000007050685,0.00001329805,0.000005036591,0.00001305272,0.00002719146],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001977377,0.0006038487,0.0002248341,0.002027617,0.0001442013,0.0007528514,0.0001449683,0.004942776,0.7997015,0.008871744,0.04147994,0.1391283],"study_design_scores_gemma":[0.001919973,0.00446202,0.0009294847,0.0002074501,0.0002540186,0.001218157,0.00006593539,0.006630544,0.7857558,0.002345168,0.1960904,0.0001210854],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.4095481,0.08465886,0.2482083,0.004468095,0.004840732,0.003547782,0.01995271,0.0105384,0.2142369],"genre_scores_gemma":[0.7520294,0.06850025,0.07460145,0.002020003,0.0006218766,0.001147295,0.01647064,0.0006611319,0.08394799],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009018003,"threshold_uncertainty_score":0.03016824,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01863561538658772,"score_gpt":0.2386759744862937,"score_spread":0.2200403590997059,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}