{"id":"W2949120013","doi":"10.1016/j.antiviral.2019.104542","title":"Passaging of an influenza A(H1N1)pdm09 virus in a difluoro sialic acid inhibitor selects for a novel, but unfit I106M neuraminidase mutant","year":2019,"lang":"en","type":"article","venue":"Antiviral Research","topic":"Influenza Virus Research Studies","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; Genome British Columbia","keywords":"Neuraminidase; Sialic acid; Virus; Biology; Wild type; Mutant; Virology; Influenza A virus; Hemagglutinin (influenza); Titer; Orthomyxoviridae; Neuraminidase inhibitor; Molecular biology; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000245084,0.0005199909,0.0004263842,0.0001894304,0.000270164,0.0003815954,0.0005816591,0.0005604564,0.001032705],"category_scores_gemma":[0.0002401743,0.0002348334,0.0004589665,0.0001919916,0.0002447428,0.000208619,0.0003123048,0.0007513143,0.0005592278],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005375906,"about_ca_system_score_gemma":0.0002346928,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003670805,"about_ca_topic_score_gemma":0.00323963,"domain_scores_codex":[0.9997057,0.00005041276,0.00003984161,0.00006114143,0.00007959561,0.00006322694],"domain_scores_gemma":[0.9997801,0.00007630467,0.00003919689,0.00003944731,0.00001852031,0.00004647094],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008450956,0.00004276128,0.0001879477,0.000008791354,0.000007742982,0.00006131764,0.00001826403,0.00009461932,0.9989811,0.00009376719,0.00004122007,0.0003779541],"study_design_scores_gemma":[0.00001805497,0.0003336628,0.002225921,0.000003360587,0.00001483182,0.0003333554,0.0000380146,0.002129994,0.9937451,0.0000219764,0.001126448,0.000009246626],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995299,0.0001581634,0.002454993,0.00009637608,0.00007752119,0.00005026138,0.0004430092,0.00005450013,0.001366283],"genre_scores_gemma":[0.9890025,0.000149006,0.005596487,0.00006710508,0.00001832785,0.00003770563,0.001252353,0.00008497517,0.003791553],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003670805,"threshold_uncertainty_score":0.007298887,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1692887561766742,"score_gpt":0.46163906468421,"score_spread":0.2923503085075358,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}