{"id":"W2949129415","doi":"10.1021/ol0061541","title":"A Formal Total Synthesis of the Sesterterpenoid (±)-Dysidiolide and Approaches to the Syntheses of (±)-6-Epi-, (±)-15-Epi-, and (±)-6,15-Bisepidysidiolide","year":2000,"lang":"en","type":"article","venue":"Organic Letters","topic":"Marine Sponges and Natural Products","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Chemistry; Total synthesis; Formal synthesis; Metabolite; Stereochemistry; Sponge; Combinatorial chemistry; Biochemistry; Botany","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000324704,0.0002327681,0.0003005069,0.00003588443,0.000130244,0.00002610348,0.0003515004,0.00009501452,0.00008880555],"category_scores_gemma":[0.0002659944,0.0001378466,0.0001018885,0.000165603,0.0002357233,0.00001656425,0.00034204,0.0001284891,0.000003581916],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009032031,"about_ca_system_score_gemma":0.00003255826,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006765951,"about_ca_topic_score_gemma":0.00007994488,"domain_scores_codex":[0.9986668,0.000133209,0.0003077177,0.000398398,0.0001763985,0.0003174806],"domain_scores_gemma":[0.9990659,0.00009257108,0.0001230746,0.0006113057,0.00002649178,0.00008066984],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001853491,0.00004412453,0.002072931,0.0001233746,0.0001602227,0.000001718391,0.0003079931,0.0000536519,0.9436317,0.00004890795,0.001440069,0.05192993],"study_design_scores_gemma":[0.0002553302,0.0001568142,0.02652176,0.00007667047,0.0001233661,0.0001569877,0.0001287743,0.00004744854,0.9666016,0.00001696696,0.00562893,0.0002853303],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9898716,0.000674282,0.00003094036,0.008606697,0.00006644747,0.0003547715,0.00003236575,0.000007518231,0.0003553802],"genre_scores_gemma":[0.9979612,0.0002099728,0.0001773441,0.001166087,0.0001889718,0.00001774188,0.000004738636,0.00002898121,0.0002449475],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0516446,"threshold_uncertainty_score":0.5621222,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01313818059841579,"score_gpt":0.1859661722549384,"score_spread":0.1728279916565226,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}