{"id":"W2949129415","doi":"10.1021/ol0061541","title":"A Formal Total Synthesis of the Sesterterpenoid (±)-Dysidiolide and Approaches to the Syntheses of (±)-6-Epi-, (±)-15-Epi-, and (±)-6,15-Bisepidysidiolide","year":2000,"lang":"en","type":"article","venue":"Organic Letters","topic":"Marine Sponges and Natural Products","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Chemistry; Total synthesis; Formal synthesis; Metabolite; Stereochemistry; Sponge; Combinatorial chemistry; Biochemistry; Botany","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001933119,0.0007480797,0.000374809,0.0004346241,0.0002951158,0.0002885426,0.0003541562,0.0002110164,0.003003261],"category_scores_gemma":[0.0001852584,0.0001855425,0.0003545734,0.0005002536,0.0003022268,0.0003627066,0.0004457732,0.0009013712,0.00158705],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003673645,"about_ca_system_score_gemma":0.001139212,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007093397,"about_ca_topic_score_gemma":0.001608778,"domain_scores_codex":[0.9998792,0.00001172171,0.00001441105,0.00002089251,0.00004176169,0.00003198574],"domain_scores_gemma":[0.9998719,0.000017026,0.00002065277,0.00002391846,0.0000282865,0.00003833907],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000750133,0.00004532542,0.00006721206,0.00020197,0.00001600938,0.0001566301,0.00006792662,0.0004376798,0.9810246,0.002602643,0.0002035013,0.01510154],"study_design_scores_gemma":[0.00004698943,0.0005170734,0.0005305461,0.00002344005,0.00004283752,0.0004222367,0.0000454246,0.0003298077,0.9685032,0.001180412,0.02832232,0.00003571483],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.564072,0.008866065,0.3589129,0.0008163643,0.0008742405,0.001406505,0.00626564,0.001370705,0.05741557],"genre_scores_gemma":[0.8493122,0.01356263,0.1056077,0.0002289201,0.00007294577,0.0006539355,0.004882171,0.0002376856,0.02544177],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003003261,"threshold_uncertainty_score":0.01004696,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01313818059841579,"score_gpt":0.1859661722549384,"score_spread":0.1728279916565226,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}