{"id":"W2949138915","doi":"10.1101/048520","title":"Temperature-dependent changes in neuronal dynamics in a patient with an <i>SCN1A</i> mutation and hyperthermia induced seizures","year":2016,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Epilepsy research and treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"Natural Sciences and Engineering Research Council of Canada; Wellcome Trust","keywords":"Dravet syndrome; Sodium channel; Chinese hamster ovary cell; Mutation; Depolarization; Neuroscience; Epilepsy; Biology; Chemistry; Genetics; Biophysics; Gene; Receptor; Sodium","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008978116,0.0002576851,0.0002930835,0.0001589637,0.0002622441,0.0002260041,0.0002102911,0.0006650634,0.0005438746],"category_scores_gemma":[0.0005509731,0.0001460445,0.0002835588,0.0001038087,0.0003232155,0.0001446872,0.0001940258,0.0004420509,0.0001089844],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003321752,"about_ca_system_score_gemma":0.00009694775,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002204987,"about_ca_topic_score_gemma":0.001726102,"domain_scores_codex":[0.9999417,0.00001263526,0.000005841043,0.00001812362,0.00001131774,0.00001030982],"domain_scores_gemma":[0.9998487,0.00008583444,0.00001968809,0.0000115154,0.000007548451,0.00002672503],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"case_report","study_design_gemma":"case_report","study_design_scores_codex":[0.002055045,0.0004196185,0.149498,0.0001058578,0.0001308247,0.5837765,0.002334615,0.05359722,0.1898943,0.001993493,0.001221062,0.01497353],"study_design_scores_gemma":[0.0002051405,0.002502958,0.2251655,0.00004648031,0.0001584438,0.365974,0.000846505,0.3203291,0.07896946,0.003355899,0.002282129,0.0001643925],"study_design_candidate":"case_report","study_design_consensus":"case_report","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988232,0.00001855257,0.0007692939,0.000109701,0.000004371879,0.000003897296,0.000046937,0.00002192625,0.0002021121],"genre_scores_gemma":[0.9995326,0.00001563536,0.0003525703,0.00001690436,0.000002549413,0.000001401531,0.00001946762,0.000006245969,0.00005280423],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002204987,"threshold_uncertainty_score":0.004384339,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01213192113722022,"score_gpt":0.2361634365777595,"score_spread":0.2240315154405393,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}