{"id":"W2949168307","doi":"10.82308/16636","title":"Synthesis, characterizations and applications of C2'-modified oligonucleotide analogues","year":2007,"lang":"en","type":"article","venue":"eScholarship@McGill (McGill)","topic":"DNA and Nucleic Acid Chemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; Fonds Québécois de la Recherche sur la Nature et les Technologies; Natural Sciences and Engineering Research Council of Canada; McGill University","keywords":"Oligonucleotide; Phosphoramidite; RNA; Ribozyme; RNase H; Aptamer; RNA splicing; Nucleotide; Chemistry; DNA; Stereochemistry; Oligonucleotide synthesis; Combinatorial chemistry; Biology; Biochemistry; Gene; Molecular biology; RNase P","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001961045,0.0003000963,0.000175525,0.0001618335,0.0001186388,0.000162524,0.0001737329,0.0003069645,0.001941348],"category_scores_gemma":[0.0003415141,0.0001176579,0.0001630761,0.0002047073,0.0001051346,0.0001291309,0.00008688878,0.0002462131,0.0005803558],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001639907,"about_ca_system_score_gemma":0.0001554718,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000318887,"about_ca_topic_score_gemma":0.0004877156,"domain_scores_codex":[0.9998434,0.00002546544,0.00001696872,0.00004116023,0.00005049881,0.00002256849],"domain_scores_gemma":[0.999862,0.00002972523,0.00002501693,0.00001623198,0.00005035115,0.00001670122],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004212714,0.00001324052,0.0000461093,0.0000685331,0.000002602115,0.0000462945,0.00001743004,0.0002109825,0.9964514,0.00008278489,0.00004823038,0.002970247],"study_design_scores_gemma":[0.00000660948,0.0003790666,0.0005807517,0.000005483394,0.000006152704,0.0001086754,0.00001125229,0.0003262887,0.9912233,0.00001715092,0.00732821,0.000006987997],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9620869,0.005598356,0.01875986,0.00008240442,0.0001092516,0.0003936798,0.0009431819,0.0001426736,0.01188367],"genre_scores_gemma":[0.9469959,0.003389303,0.03346035,0.0001500705,0.0000372437,0.0004372996,0.001906083,0.00007543717,0.01354836],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001941348,"threshold_uncertainty_score":0.006494462,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008593714486185601,"score_gpt":0.2236036906403244,"score_spread":0.2150099761541388,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}