{"id":"W2949176444","doi":"10.3892/ol.2019.10518","title":"Imatinib mesylate and nilotinib decrease synthesis of bone matrix in�vitro","year":2019,"lang":"en","type":"article","venue":"Oncology Letters","topic":"Chronic Myeloid Leukemia Treatments","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Children's Hospital","funders":"Technische Universität Dresden","keywords":"RANKL; Osteoprotegerin; Bone remodeling; Osteoblast; Imatinib mesylate; Nilotinib; Cancer research; Osteocalcin; Internal medicine; Medicine; Chemistry; Endocrinology; Myeloid leukemia; Activator (genetics); Imatinib; Alkaline phosphatase; Receptor; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002669533,0.0001600207,0.0006605546,0.000189928,0.0000155867,0.000003159456,0.00005703798,0.0001285964,0.0003412651],"category_scores_gemma":[0.0002412261,0.0001412264,0.00007451235,0.0001230925,0.0001281995,0.00005050228,0.00005405768,0.0001811593,0.0001155345],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005441266,"about_ca_system_score_gemma":0.0002595103,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002115387,"about_ca_topic_score_gemma":0.000012712,"domain_scores_codex":[0.998812,0.0000933544,0.0003728777,0.0002879786,0.0001449356,0.0002889067],"domain_scores_gemma":[0.9988605,0.0004990071,0.0001663089,0.0003087146,0.00002030452,0.0001451544],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002268292,0.0005015152,0.106221,0.0004257363,0.0002626152,0.0009963614,0.0005108079,0.000009940358,0.8650587,0.00007426085,0.00190545,0.02176535],"study_design_scores_gemma":[0.06400225,0.002657228,0.4291045,0.00131107,0.001840949,0.003142085,0.0008512845,0.001786409,0.4675505,0.0001559742,0.02637269,0.001225005],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9891637,0.000265425,0.000003915867,0.007045451,0.0001092075,0.0004890191,0.00001121516,0.00002753338,0.002884522],"genre_scores_gemma":[0.9928103,0.00006149873,0.004664817,0.002044247,0.00003837614,0.00004105098,0.00001463275,0.00002501534,0.0003000536],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3975081,"threshold_uncertainty_score":0.5759044,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009162864746320094,"score_gpt":0.283428120952737,"score_spread":0.2742652562064169,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}