{"id":"W2949176444","doi":"10.3892/ol.2019.10518","title":"Imatinib mesylate and nilotinib decrease synthesis of bone matrix in�vitro","year":2019,"lang":"en","type":"article","venue":"Oncology Letters","topic":"Chronic Myeloid Leukemia Treatments","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Children's Hospital","funders":"Technische Universität Dresden","keywords":"RANKL; Osteoprotegerin; Bone remodeling; Osteoblast; Imatinib mesylate; Nilotinib; Cancer research; Osteocalcin; Internal medicine; Medicine; Chemistry; Endocrinology; Myeloid leukemia; Activator (genetics); Imatinib; Alkaline phosphatase; Receptor; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001231638,0.0002759366,0.0002655177,0.0002800683,0.0001212784,0.0001890738,0.0001117194,0.0002648235,0.002575766],"category_scores_gemma":[0.0001661203,0.00009300765,0.0001588537,0.0001810509,0.0001517661,0.0001647202,0.0001952083,0.0003729934,0.000434983],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002066566,"about_ca_system_score_gemma":0.0002369491,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002681572,"about_ca_topic_score_gemma":0.0008245616,"domain_scores_codex":[0.9998227,0.00003385749,0.00001834669,0.00002038633,0.0000697986,0.000034889],"domain_scores_gemma":[0.9999344,0.00001127197,0.00002236319,0.000003617895,0.00001039852,0.00001788722],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006605758,0.0001475774,0.0008460633,0.0004022635,0.00002176941,0.0001902718,0.00002923031,0.000133411,0.9640501,0.0005859702,0.001189615,0.03174315],"study_design_scores_gemma":[0.0004634862,0.004391178,0.02792545,0.00004593925,0.00007639616,0.002045532,0.0001355364,0.001443796,0.886305,0.0006321791,0.07651177,0.0000236739],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9176899,0.06287552,0.003035791,0.001466877,0.0003770092,0.0001411854,0.001024021,0.0001775407,0.01321217],"genre_scores_gemma":[0.9819661,0.009583742,0.001633607,0.0003745072,0.00005794367,0.0001125029,0.0006518465,0.00001391871,0.005605852],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002575766,"threshold_uncertainty_score":0.008616745,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009162864746320094,"score_gpt":0.283428120952737,"score_spread":0.2742652562064169,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}