{"id":"W2949196339","doi":"10.1002/chin.200741210","title":"α‐Substituted 1‐Aryl‐3‐dimethylaminopropanone Hydrochlorides: Potent Cytotoxins Towards Human WiDr Colon Cancer Cells.","year":2007,"lang":"en","type":"article","venue":"ChemInform","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"","keywords":"Chemistry; Aryl; Cytotoxicity; Combinatorial chemistry; Cancer; Colorectal cancer; Stereochemistry; Cancer research; Biochemistry; Organic chemistry; In vitro; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0003399914,0.0003723731,0.000437089,0.0000549878,0.0002271312,0.00004884218,0.0004323852,0.0004170305,0.002599927],"category_scores_gemma":[0.0001143607,0.0002872008,0.0002165366,0.0002075908,0.0002081762,0.0001706518,0.0001679754,0.0003641212,0.00008440523],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000413233,"about_ca_system_score_gemma":0.00009670651,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004580298,"about_ca_topic_score_gemma":0.0002002783,"domain_scores_codex":[0.9979712,4.980154e-7,0.0004989406,0.0004489338,0.0003786558,0.000701756],"domain_scores_gemma":[0.9988323,0.0001298769,0.0002413007,0.0004385656,0.0000964815,0.0002614344],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007832506,0.0001904749,0.0003893915,0.000116985,0.00005692269,0.00002949581,0.00008982413,6.716999e-7,0.8786744,0.00003356786,0.0005796321,0.1197603],"study_design_scores_gemma":[0.0004516594,0.0000350308,0.003046895,0.00007547325,0.00004177128,0.000009849039,0.0001250838,0.00001088235,0.9792037,0.00006504493,0.0164977,0.0004369191],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7564412,0.0001490867,0.000005815031,0.00005221038,0.0001412599,0.0001057963,0.00004157741,0.0001827413,0.2428803],"genre_scores_gemma":[0.9928284,0.000123923,0.00007761021,0.0001395954,0.0005394402,0.00005556896,0.00007246231,0.00002637762,0.006136665],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2367436,"threshold_uncertainty_score":0.999958,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02496979602948916,"score_gpt":0.2711932807917208,"score_spread":0.2462234847622317,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}